SV40感染的CV-1细胞中的多核糖体和多核糖体mRNA。体内观察结果。

Polysomes and polysomal mRNAs in SV40-infected CV-1 cells. In vivo observations.

作者信息

Ho-Terry L, Terry G M, Cohen A

出版信息

Biochim Biophys Acta. 1978 Jul 24;519(2):390-7. doi: 10.1016/0005-2787(78)90092-8.

PMID:208616

Abstract

SV40-specific polysomes are relatively larger than host polysomes. Both 16 S and 19 S virus-specific late mRNAs are found associated with these polysomes and they are present in a ratio of approximately 2 : 1. The rates at which these virus-specific mRNAs are translated are the same, so that the relative amounts of virus-specific polypeptides synthesized in the virus-infected cells is determined by the relative amounts of 16 S and 19 S mRNAs coding for them.

摘要

SV40特异性多核糖体比宿主多核糖体相对更大。16S和19S病毒特异性晚期mRNA均被发现与这些多核糖体相关联，且它们以大约2:1的比例存在。这些病毒特异性mRNA的翻译速率相同，因此在病毒感染细胞中合成的病毒特异性多肽的相对量由编码它们的16S和19S mRNA的相对量决定。