Royal Free Hampstead NHS trust, UK.
J Clin Gastroenterol. 2011 Jan;45(1):e8-11. doi: 10.1097/MCG.0b013e3181e04d3c.
Synchronous malignant neoplasms in a single patient are well documented in the literature. It is also recognized that there is increasing incidence of synchronous non-neuroendocrine neoplasm in patients with neuroendocrine tumor (NET). We present a case, of a patient with synchronous colorectal cancer and pancreatic NET, both cancers presenting with liver metastasis. By using 18F-FDG PET and 68Ga-DOTATATE PET imaging, we showed 2 different tumor types within the liver, which was subsequently confirmed on liver biopsy. This case report shows the utility of molecular imaging using different PET peptides. These newer modalities are useful in understanding the biology of the NET and in determining the best patient management.
在文献中有充分的证据表明，单个患者中存在同时发生的恶性肿瘤。此外，人们还认识到，患有神经内分泌肿瘤（NET）的患者中同时发生非神经内分泌肿瘤的发病率正在上升。我们报告了 1 例同时患有结直肠癌和胰腺神经内分泌肿瘤的患者，这两种癌症均表现为肝转移。通过使用 18F-FDG PET 和 68Ga-DOTATATE PET 成像，我们在肝脏中显示了两种不同的肿瘤类型，随后在肝活检中得到了证实。该病例报告展示了使用不同的 PET 肽进行分子成像的效用。这些新方法对于了解 NET 的生物学特性以及确定最佳患者管理非常有用。
