The State Key Laboratory of Genetic Engineering, Shanghai, China.
J Invest Dermatol. 2011 Jan;131(1):220-8. doi: 10.1038/jid.2010.270. Epub 2010 Sep 23.
The TP53 gene has an important role in the protection of cells from DNA damage due to UV exposure, and sequence variation in the gene may alter skin cancer susceptibility. To examine the association between the TP53 Arg72Pro polymorphism and skin cancer risk, we undertook a meta-analysis of 15 case-control studies involving 6,362 subjects. The quality of the studies was assessed according to a predefined scale. Crude odds ratios (ORs) with 95% confidence intervals (CIs) were assessed for association using a random-effects model. Overall, no evidence of association was observed between TP53 genotypes and the risk of skin cancer in any genetic model (Arg/Arg vs. Pro/Pro: OR=1.05, 95% CI: 0.71-1.55; Arg/Pro vs. Pro/Pro: OR=0.92, 95% CI: 0.68-1.24; Arg/Arg+Arg/Pro vs. Pro/Pro: OR=0.97, 95% CI: 0.70-1.35; Arg/Arg vs. Arg/Pro+Pro/Pro: OR=1.15, 95% CI: 0.91-1.46). Stratified analyses according to ethnicity and quality score of the studies also detected no significant association in any subgroup. Furthermore, no effect of this polymorphism on subtype of skin cancer, such as melanoma, squamous cell carcinoma, and basal cell carcinoma, was observed. In conclusion, this meta-analysis suggests that the TP53 Arg72Pro polymorphism may have little involvement in skin cancer susceptibility.
TP53 基因在保护细胞免受紫外线引起的 DNA 损伤方面起着重要作用，基因序列的变异可能会改变皮肤癌的易感性。为了研究 TP53 Arg72Pro 多态性与皮肤癌风险之间的关联，我们对涉及 6362 名受试者的 15 项病例对照研究进行了荟萃分析。根据预先确定的标准评估研究的质量。使用随机效应模型评估关联的粗比值比（OR）和 95%置信区间（CI）。总体而言，在任何遗传模型中，TP53 基因型与皮肤癌风险之间均未见关联（Arg/Arg 与 Pro/Pro：OR=1.05，95%CI：0.71-1.55；Arg/Pro 与 Pro/Pro：OR=0.92，95%CI：0.68-1.24；Arg/Arg+Arg/Pro 与 Pro/Pro：OR=0.97，95%CI：0.70-1.35；Arg/Arg 与 Arg/Pro+Pro/Pro：OR=1.15，95%CI：0.91-1.46）。根据种族和研究质量评分进行的分层分析也未在任何亚组中检测到显著关联。此外，该多态性对皮肤癌的亚型（如黑色素瘤、鳞状细胞癌和基底细胞癌）也没有影响。总之，这项荟萃分析表明，TP53 Arg72Pro 多态性可能与皮肤癌易感性关系不大。
