Department of Anesthesiology, Suzhou Kowloon Hospital, Shanghai Jiaotong University School of Medcine, Suzhou, 215028, People's Republic of China.
Department of Clinical Laboratory, First Affiliated Hospital of Soochow University, 188 Shizi Road, Suzhou, 215006, People's Republic of China.
BMC Med Genet. 2020 Mar 30;21(1):63. doi: 10.1186/s12881-020-01006-0.
Brucellosis is a quite normal zoonotic infection, which is caused by immediate contact with animals infected with Brucella or its products. IL-10 (- 1082 G/A, - 819 C/T, - 592C/A) and IL-6 -174 G/C polymorphisms have a great relationship with IL-10 and IL-6 production, which brings about Brucellosis pathogenesis and development. So far, the results of published literatures were controversial. Now, we perform a meta-analysis in different ethnic populations to get a more precise estimate of above polymorphisms with Brucellosis susceptibility.
Both OR and corresponding 95%CI were enrolled to make an assessment of the association strength through extracting genotyping frequency of cases and controls. The χ2-test based Q-statistic and I statistics were applied. If there was no evident heterogeneity, the fixed-effects model would be applied. If not, the random-effects model would be used.
The significant associations were only found in Asian population of - 819 loci under three genetic models as follows: (Allele model: OR = 0.60, 95%CI = 0.44-0.82, P = 0.001), (homozygote comparison: OR = 0.24, 95%CI = 0.09-0.62, P = 0.003), (recessive genetic model: OR = 0.22, 95%CI = 0.05-0.91, P = 0.036).
In conclusion, IL-10 - 819 loci polymorphism contributes no risk to Caucasian population but may be associated with decreased risk in Asian population. And IL-10 -1082 G/A, 592 loci and IL-6 -174 G/C polymorphism are not associated with Brucellosis risk.
布鲁氏菌病是一种常见的人畜共患传染病，由直接接触感染布鲁氏菌或其产物的动物引起。IL-10（-1082G/A、-819C/T、-592C/A）和 IL-6-174G/C 多态性与 IL-10 和 IL-6 的产生密切相关，导致布鲁氏菌病的发病和发展。到目前为止，已发表文献的结果存在争议。现在，我们在不同的种族人群中进行荟萃分析，以更准确地评估上述多态性与布鲁氏菌病易感性的关系。
通过提取病例和对照的基因分型频率，纳入 OR 和相应的 95%CI 来评估关联强度。基于 χ2检验的 Q 统计量和 I 统计量用于评估异质性。如果没有明显的异质性，将采用固定效应模型。如果存在异质性，则采用随机效应模型。
仅在三个遗传模型下，亚洲人群的-819 位发现了显著的关联：（等位基因模型：OR=0.60，95%CI=0.44-0.82，P=0.001），（纯合子比较：OR=0.24，95%CI=0.09-0.62，P=0.003），（隐性遗传模型：OR=0.22，95%CI=0.05-0.91，P=0.036）。
总之，IL-10-819 位多态性对高加索人群没有增加风险，但可能与亚洲人群的低风险有关。IL-10-1082G/A、592 位和 IL-6-174G/C 多态性与布鲁氏菌病风险无关。
