Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Emergency Department, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, PR China.
Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Department of Orthopedic, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, PR China.
Biosci Rep. 2020 Jan 31;40(1). doi: 10.1042/BSR20191449.
Interleukin-21 (IL-21) is a cytokine that plays a crucial role in pathogenesis and activity of the rheumatoid arthritis (RA). Meanwhile, genetic polymorphisms in the IL-21 gene may alter its expression. Previous studies have reported conflicting results assessing the association between the IL-21 rs6822844 G/T polymorphism and RA risk. Thus, it's necessary to perform a meta-analysis to definite above relationship. PubMed database was searched for all papers published until October 20, 2019. Nine case-control studies with 9998 cases and 10742 controls were retrieved based on the search criteria at last. Odds ratio (95% confidence interval) was used to calculate the strength of this association. Publication bias was detected using both Begg's and Egger's tests. Overall, the IL-21 rs6822844 G/T polymorphism was found to be significantly associated with decreased RA risk (e.g. T-allele versus G-allele: OR = 0.81, 95% CI = 0.72-0.91, P < 0.001). In addition, decreased RA risk was also detected both in Asians (eg: TT+TG versus GG: OR = 0.42, 95% CI = 0.31-0.56, P < 0.001) and Caucasians (eg: TT+TG versus GG: OR = 0.85, 95% CI = 0.80-0.91, P < 0.001). A similar trend in association was found in the source of the control and genotype method subgroups. Furthermore, subgroup analysis of rheumatoid factor status revealed a protective relationship between the IL-21 rs6822844 G/T polymorphism and RF+/RF- RA risk. A similar relationship was noted in the anti-citrullinated protein antibody status subgroup. The results of the present study suggest that the IL-21 rs6822844 G/T polymorphism was significantly associated with decreased RA susceptibility.
白细胞介素-21（IL-21）是一种细胞因子，在类风湿关节炎（RA）的发病机制和活动中起着至关重要的作用。同时，IL-21 基因的遗传多态性可能改变其表达。先前的研究报告了评估 IL-21 rs6822844 G/T 多态性与 RA 风险之间关联的相互矛盾的结果。因此，有必要进行荟萃分析以明确上述关系。在 PubMed 数据库中搜索截至 2019 年 10 月 20 日发表的所有论文。根据搜索标准，最后检索到 9 项病例对照研究，共 9998 例病例和 10742 例对照。使用比值比（95%置信区间）来计算这种关联的强度。使用 Begg 和 Egger 检验检测发表偏倚。总的来说，IL-21 rs6822844 G/T 多态性与降低 RA 风险显著相关（例如，T 等位基因与 G 等位基因：OR=0.81，95%CI=0.72-0.91，P<0.001）。此外，在亚洲人（例如：TT+TG 与 GG：OR=0.42，95%CI=0.31-0.56，P<0.001）和高加索人（例如：TT+TG 与 GG：OR=0.85，95%CI=0.80-0.91，P<0.001）中也检测到降低 RA 风险的趋势。在对照和基因型方法亚组的来源中也发现了类似的关联趋势。此外，类风湿因子状态的亚组分析显示，IL-21 rs6822844 G/T 多态性与 RF+/RF-RA 风险之间存在保护关系。在抗瓜氨酸蛋白抗体状态亚组中也注意到了类似的关系。本研究的结果表明，IL-21 rs6822844 G/T 多态性与降低 RA 易感性显著相关。
