Trimarco B, Ricciardelli B, Cuocolo A, Picotti G B, Galva M D, De Simone A, De Luca N
J Hypertens Suppl. 1985 Dec;3(4):S101-3.
In 10 normotensives with both parents hypertensive, the relationship between changes in echocardiographic parameters of left ventricular anatomy and those in circulating catecholamine levels induced by three 3-week periods of different sodium and potassium intakes were examined. A high-sodium normal-potassium regimen reduced upright plasma norepinephrine (P less than 0.01), posterior wall thickness (PWT) and interventricular septal thickness (IVST) as well as the left ventricular mass index (LVMi). Changes in upright plasma noreprinephrine correlated with those in IVST (r = 0.822, P less than 0.01) and in LVMi (r = 0.833, P less than 0.01). A low-sodium normal-potassium diet increased supine (P less than 0.001) and upright (P less than 0.01) plasma norepinephrine as well as the IVST and LVMi. The changes in supine and upright norepinephrine levels correlated with changes in IVST (r = 0.836 and r = 0.796 respectively, both P less than 0.01) and in LVMi (r = 0.931 and r = 0.947 respectively, both P less than 0.001). No significant change in any of the above parameters was detected after a low-sodium high-potassium regimen. These findings indicate that in hypertensive progeny catecholamines may play a role in the physiological regulation of left ventricular mass (LVM).
在10名双亲均患有高血压的血压正常者中，研究了不同钠钾摄入量的三个为期3周的阶段所引起的左心室解剖结构超声心动图参数变化与循环儿茶酚胺水平变化之间的关系。高钠正常钾饮食方案可降低直立位血浆去甲肾上腺素水平（P<0.01）、后壁厚度（PWT）、室间隔厚度（IVST）以及左心室质量指数（LVMi）。直立位血浆去甲肾上腺素水平的变化与IVST变化（r = 0.822，P<0.01）和LVMi变化（r = 0.833，P<0.01）相关。低钠正常钾饮食可增加仰卧位（P<0.001）和直立位（P<0.01）血浆去甲肾上腺素水平以及IVST和LVMi。仰卧位和直立位去甲肾上腺素水平的变化与IVST变化（分别为r = 0.836和r = 0.796，均P<0.01）和LVMi变化（分别为r = 0.931和r = 0.947，均P<0.001）相关。低钠高钾饮食方案后上述任何参数均未检测到显著变化。这些发现表明，在高血压后代中，儿茶酚胺可能在左心室质量（LVM）的生理调节中起作用。
