钯-双(恶唑啉)配合物催化的烯丙基烷基化反应，来源于杂芳基烯丙基丙二酸酯衍生物。
Allylic alkylations catalyzed by palladium-bis(oxazoline) complexes derived from heteroarylidene malonate derivatives.
机构信息
Department of Applied Chemistry, China Agricultural University, Beijing 100193, China.
出版信息
Molecules. 2012 Feb 17;17(2):1992-9. doi: 10.3390/molecules17021992.
Abstract
A series of simple heteroarylidene malonate-type bis(oxazoline) ligands 4 and 5 were applied to the palladium-catalyzed allylic alkylation reaction, and the ligand 4a bearing a phenyl group afforded excellent enantioselectivity (up to 96% ee) for the allylic alkylation product. Other substrates were also examined, giving the allylic alkylated products in high yield but with poor ee values.
摘要
一系列简单的杂芳亚甲基丙二酸酯型双（恶唑啉）配体 4 和 5 被应用于钯催化的烯丙基烷基化反应，带有苯基的配体 4a 为烯丙基烷基化产物提供了极好的对映选择性（高达 96%ee）。其他底物也进行了考察，得到的烯丙基烷基化产物产率高，但对映体过量值低。
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