尿液样本用于评估汞排泄和肾脏损伤标志物的方法学考虑。
Methodological considerations with the use of urine samples for assessment of mercury excretion and markers of renal damage.
机构信息
New England Research Institutes, Watertown, MA 02472, USA.
出版信息
Biomarkers. 2010 Nov;15(7):639-45. doi: 10.3109/1354750X.2010.510581. Epub 2010 Sep 23.
Abstract
OBJECTIVE
To provide recommendations for design and analysis of studies using urine specimens to evaluate renal function or mercury excretion in children.
METHODS
An analysis of mercury, albumin, γ-glutamyl transpeptidase (γ-GT) and N-acetyl-β-D-glucosaminidase (NAG) concentrations was carried out.
RESULTS
Mercury concentration and creatinine-corrected renal markers were higher in daytime compared with overnight samples. Excretion rates increased with urinary flow rate. γ-GT and NAG concentrations decreased with storage time at -20°C. Differences by age, sex and race were noted.
CONCLUSIONS
We recommend use of these creatinine-corrected markers and collection of timed overnight urine samples, stored at -70°C, with control for urinary flow rate, age, sex and race in statistical models.
摘要
目的
为使用尿液样本评估儿童肾功能或汞排泄的研究设计和分析提供建议。
方法
对汞、白蛋白、γ-谷氨酰转肽酶（γ-GT）和 N-乙酰-β-D-氨基葡萄糖苷酶（NAG）浓度进行分析。
结果
与夜间样本相比，日间的汞浓度和肌酐校正后的肾标志物浓度更高。排泄率随尿流速增加而增加。γ-GT 和 NAG 浓度随-20°C 下的储存时间而降低。注意到了年龄、性别和种族的差异。
结论
我们建议在统计模型中使用这些肌酐校正后的标志物，并收集经过时间控制的夜间尿液样本，在-70°C 下储存，同时控制尿流速、年龄、性别和种族。
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