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Effect of storage time at -20°C on markers used for assessment of renal damage in children: albumin, γ-glutamyl transpeptidase, N-acetyl-β-D-glucosaminidase and α1-microglobulin.-20°C储存时间对用于评估儿童肾损伤的标志物的影响：白蛋白、γ-谷氨酰转肽酶、N-乙酰-β-D-氨基葡萄糖苷酶和α1-微球蛋白。
Scand J Urol Nephrol. 2010 Nov;44(5):331-6. doi: 10.3109/00365599.2010.492785. Epub 2010 Jun 21.
2
The influence of urinary flow rate on mercury excretion in children.尿流率对儿童体内汞排泄的影响。
J Trace Elem Med Biol. 2010 Jan;24(1):31-5. doi: 10.1016/j.jtemb.2009.06.003. Epub 2009 Aug 5.
3
The effect of age, sex, and race on urinary markers of kidney damage in children.年龄、性别和种族对儿童肾脏损伤尿液标志物的影响。
Am J Kidney Dis. 2007 Dec;50(6):938-45. doi: 10.1053/j.ajkd.2007.08.014.
4
Scalp hair and urine mercury content of children in the Northeast United States: the New England Children's Amalgam Trial.美国东北部儿童的头皮毛发和尿液汞含量：新英格兰儿童汞合金试验
Environ Res. 2008 May;107(1):79-88. doi: 10.1016/j.envres.2007.08.015. Epub 2007 Oct 24.
5
The influence of urinary flow rate in children on excretion of markers used for assessment of renal damage: albumin, gamma-glutamyl transpeptidase, N-acetyl-beta-D -glucosaminidase, and alpha1-microglobulin.儿童尿流率对用于评估肾损伤的标志物排泄的影响：白蛋白、γ-谷氨酰转肽酶、N-乙酰-β-D-氨基葡萄糖苷酶和α1-微球蛋白。
Pediatr Nephrol. 2008 Mar;23(3):445-56. doi: 10.1007/s00467-007-0568-1. Epub 2007 Aug 18.
6
Neuropsychological and renal effects of dental amalgam in children: a randomized clinical trial.儿童牙科汞合金的神经心理学和肾脏影响：一项随机临床试验。
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7
Timed urine collections are not needed to measure urine protein excretion in clinical practice.在临床实践中，测量尿蛋白排泄量无需进行定时尿样采集。
Am J Kidney Dis. 2006 Jan;47(1):8-14. doi: 10.1053/j.ajkd.2005.10.013.
8
Timed urine collections are not needed to measure urine protein excretion in clinical practice.在临床实践中，测量尿蛋白排泄量无需进行定时尿液收集。
Am J Kidney Dis. 2006 Jan;47(1):1-7. doi: 10.1053/j.ajkd.2005.10.014.
9
The association between a genetic polymorphism of coproporphyrinogen oxidase, dental mercury exposure and neurobehavioral response in humans.粪卟啉原氧化酶基因多态性、人体牙齿汞暴露与神经行为反应之间的关联。
Neurotoxicol Teratol. 2006 Jan-Feb;28(1):39-48. doi: 10.1016/j.ntt.2005.10.006. Epub 2005 Dec 15.
10
A neurobehavioral study of chloralkali workers after the cessation of exposure to mercury vapor.汞蒸气暴露停止后氯碱工人的神经行为学研究。
Neurotoxicology. 2005 Jun;26(3):427-37. doi: 10.1016/j.neuro.2005.03.006. Epub 2005 Apr 26.

尿液样本用于评估汞排泄和肾脏损伤标志物的方法学考虑。

Methodological considerations with the use of urine samples for assessment of mercury excretion and markers of renal damage.

机构信息

New England Research Institutes, Watertown, MA 02472, USA.

出版信息

Biomarkers. 2010 Nov;15(7):639-45. doi: 10.3109/1354750X.2010.510581. Epub 2010 Sep 23.

DOI:10.3109/1354750X.2010.510581
PMID:20863154
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3580061/
Abstract

OBJECTIVE

To provide recommendations for design and analysis of studies using urine specimens to evaluate renal function or mercury excretion in children.

METHODS

An analysis of mercury, albumin, γ-glutamyl transpeptidase (γ-GT) and N-acetyl-β-D-glucosaminidase (NAG) concentrations was carried out.

RESULTS

Mercury concentration and creatinine-corrected renal markers were higher in daytime compared with overnight samples. Excretion rates increased with urinary flow rate. γ-GT and NAG concentrations decreased with storage time at -20°C. Differences by age, sex and race were noted.

CONCLUSIONS

We recommend use of these creatinine-corrected markers and collection of timed overnight urine samples, stored at -70°C, with control for urinary flow rate, age, sex and race in statistical models.

摘要

目的

为使用尿液样本评估儿童肾功能或汞排泄的研究设计和分析提供建议。

方法

对汞、白蛋白、γ-谷氨酰转肽酶（γ-GT）和 N-乙酰-β-D-氨基葡萄糖苷酶（NAG）浓度进行分析。

结果

与夜间样本相比，日间的汞浓度和肌酐校正后的肾标志物浓度更高。排泄率随尿流速增加而增加。γ-GT 和 NAG 浓度随-20°C 下的储存时间而降低。注意到了年龄、性别和种族的差异。

结论

我们建议在统计模型中使用这些肌酐校正后的标志物，并收集经过时间控制的夜间尿液样本，在-70°C 下储存，同时控制尿流速、年龄、性别和种族。