Nefedov M D, Gar'kavtsev I V, Rogaev E I
Genetika. 1990 Dec;26(12):2226-31.
Polymorphism of the human c-Ha-ras-1 gene has been analysed in 66 BamHI restricted DNAs from blood of 35 patients with "inherited" breast cancer, 7 fibroadenoma patients, 13 healthy first-degree relatives and 11 unaffected controls. Two "common" and four "unusual" alleles were detected. The frequency of "common" (6.6 and 7.4 kb) and "unusual" (6.9 kb) alleles was identical to that in the control and unaffected groups (65.8, 17.1 and 7.1%). Rare alleles (7.6 and 7.8 kb) were only detected in breast cancer patients and in healthy first-degree relatives. A 8.0 kb allele specific for control patients was also detected. No absolute relationship between the genetic predisposition to breast cancer and the Ha-ras genotype was assumed.
对35例“遗传性”乳腺癌患者、7例纤维腺瘤患者、13名健康的一级亲属和11名未受影响的对照者血液中经BamHI酶切的66份DNA进行了人类c-Ha-ras-1基因多态性分析。检测到两个“常见”等位基因和四个“罕见”等位基因。“常见”（6.6和7.4 kb）和“罕见”（6.9 kb）等位基因的频率与对照组和未受影响组相同（65.8%、17.1%和7.1%）。仅在乳腺癌患者和健康的一级亲属中检测到罕见等位基因（7.6和7.8 kb）。还检测到一个对照组特有的8.0 kb等位基因。未发现乳腺癌遗传易感性与Ha-ras基因型之间存在绝对关联。
