Laboratory for Cancer Medicine, University of Western Australia Centre for Medical Research, Western Australian Institute for Medical Research, Perth, Western Australia 6000, Australia.
Curr Opin Pharmacol. 2010 Dec;10(6):655-61. doi: 10.1016/j.coph.2010.08.011. Epub 2010 Sep 21.
Recent years have seen a massive expansion in our understanding of the biology of microRNAs (miRNAs) in cancer, through the identification of miRNAs with aberrant expression in specific cancers and the functional validation of their critical target molecules and cellular effects. In parallel, targeted therapeutic agents to block signalling pathways critical to tumour growth and progression have been developed but have yielded disappointing clinical results. The discovery of miRNAs that regulate ErbB signalling in cancer cells brings new hope that in the future these oncogenic pathways can be more effectively inhibited to improve patient outcomes.
近年来，通过鉴定在特定癌症中表达异常的 miRNAs 以及对其关键靶分子和细胞效应的功能验证，我们对 miRNA 在癌症中的生物学作用有了更深入的了解。与此同时，为了阻断对肿瘤生长和转移至关重要的信号通路，已经开发出了靶向治疗药物，但临床疗效却不尽人意。发现调节癌细胞中 ErbB 信号的 miRNA 为我们带来了新的希望，即未来可以更有效地抑制这些致癌途径，以改善患者的预后。
