Institute of Chemical and Metabolism of Drugs, University of Buenos Aires, National Council of Scientific and Technical Research (QUIMEFA-UBA-CONICET), Buenos Aires, Argentina.
Hum Exp Toxicol. 2011 Aug;30(8):965-71. doi: 10.1177/0960327110384523. Epub 2010 Sep 23.
Larrea divaricata is a plant widely used in folk medicine in Argentina. It has been demonstrated that an aqueous extract of L. divaricata possesses a biphasic effect on cell proliferation, at low concentrations exerts a stimulatory action and at high concentrations exerts anti-proliferative effects upon the T lymphoma BW 5147; therefore, we propose in this paper to test the effect of the extract 'in vitro' and 'in vivo' in another T-cell lymphoma named EL-4. It was analyzed 'in vitro' cell proliferation by tritiated thymidine uptake and the effect of the extract on tumors induced in mice analyzing tumor progression and survival.The results showed that the aqueous extract induced the proliferation of tumor cells at all the concentrations studied. The results 'in vivo' showed that the aqueous extract stimulated significantly the size of tumors and that untreated mice lived longer than those treated. It is important to be very careful when plant extracts are selected for the treatment of several diseases. Consequently, before using a plant extract, specific scientific studies must be undertaken on different models to certificate therapeutic and adverse effects. Moreover, it can be said that L. divaricata has a specific anti-tumor mechanism of action depending on the targets.
拉雷亚分裂是一种在阿根廷民间医学中广泛使用的植物。已经证明，拉雷亚分裂的水提取物对细胞增殖具有双相作用，在低浓度下表现出刺激作用，在高浓度下对 T 淋巴瘤 BW 5147 表现出抗增殖作用；因此，我们在本文中提出了在另一种 T 细胞淋巴瘤 EL-4 中测试提取物的“体外”和“体内”作用。通过氚标记胸腺嘧啶摄取分析了“体外”细胞增殖，并且通过分析肿瘤进展和存活来研究提取物对在小鼠中诱导的肿瘤的作用。结果表明，水提取物在研究的所有浓度下均诱导肿瘤细胞增殖。体内结果表明，水提取物显着刺激肿瘤的大小，并且未经处理的小鼠比经处理的小鼠存活时间更长。在选择用于治疗多种疾病的植物提取物时，必须非常小心。因此，在使用植物提取物之前，必须在不同的模型上进行特定的科学研究，以证明治疗效果和不良反应。此外，可以说拉雷亚分裂具有取决于靶标的特定抗肿瘤作用机制。
