Nutritional Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA.
Am J Public Health. 2010 Nov;100(11):2288-95. doi: 10.2105/AJPH.2009.180828. Epub 2010 Sep 23.
We prospectively examined nonrecreational physical activity and sedentary behavior in relation to breast cancer risk among 97 039 postmenopausal women in the National Institutes of Health-AARP Diet and Health Study.
We identified 2866 invasive and 570 in situ breast cancer cases recorded between 1996 and 2003 and used Cox proportional hazards regression to estimate multivariate relative risks (RRs) and 95% confidence intervals (CIs).
Routine activity during the day at work or at home that included heavy lifting or carrying versus mostly sitting was associated with reduced risk of invasive breast cancer (RR = 0.62; 95% CI = 0.42, 0.91; P(trend) = .024).
Routine activity during the day at work or home may be related to reduced invasive breast cancer risk. Domains outside of recreation time may be attractive targets for increasing physical activity and reducing sedentary behavior among postmenopausal women.
我们前瞻性地研究了非娱乐性体力活动和久坐行为与美国国立卫生研究院-美国退休人员协会饮食与健康研究中 97039 名绝经后女性乳腺癌风险之间的关系。
我们确定了 1996 年至 2003 年间记录的 2866 例浸润性乳腺癌和 570 例原位乳腺癌病例,并使用 Cox 比例风险回归估计多变量相对风险(RR)和 95%置信区间(CI)。
与主要坐着相比,工作或在家中的日常活动包括重物搬运或携带与浸润性乳腺癌风险降低相关(RR = 0.62;95%CI = 0.42,0.91;P(趋势)=.024)。
工作或在家中的日常活动可能与降低浸润性乳腺癌风险有关。除了娱乐时间之外,其他领域可能是增加绝经后女性体力活动和减少久坐行为的有吸引力的目标。