Baker IDIHeart and Diabetes Institute, Melbourne, Victoria, Australia.
Diabetes Care. 2010 Feb;33(2):327-34. doi: 10.2337/dc09-0493. Epub 2009 Nov 16.
We examined the associations of sitting time and television (TV) viewing time with continuously measured biomarkers of cardio-metabolic risk in Australian adults.
Waist circumference, BMI, resting blood pressure, triglycerides, HDL cholesterol, fasting and 2-h postload plasma glucose, and fasting insulin were measured in 2,761 women and 2,103 men aged > or =30 years (mean age 54 years) without clinically diagnosed diabetes from the 2004-2005 Australian Diabetes, Obesity and Lifestyle (AusDiab) study. Multivariate linear regression analyses examined associations of self-reported sitting time and TV viewing time (hours per day) with these biomarkers, adjusting for potential confounding variables.
For both women and men, sitting time was detrimentally associated with waist circumference, BMI, systolic blood pressure, fasting triglycerides, HDL cholesterol, 2-h postload plasma glucose, and fasting insulin (all P < 0.05), but not with fasting plasma glucose and diastolic blood pressure (men only). With the exception of HDL cholesterol and systolic blood pressure in women, the associations remained significant after further adjustment for waist circumference. TV viewing time was detrimentally associated with all metabolic measures in women and all except HDL cholesterol and blood pressure in men. Only fasting insulin and glucose (men only) remained deleteriously associated with TV viewing time after adjustment for waist circumference.
In women and men, sitting time and TV viewing time were deleteriously associated with cardio-metabolic risk biomarkers, with sitting time having more consistent associations in both sexes and being independent of central adiposity. Preventive initiatives aimed at reducing sitting time should focus on both nonleisure and leisure-time domains.
我们研究了澳大利亚成年人久坐时间和看电视时间与连续测量的心血管代谢风险生物标志物之间的关联。
在 2004-2005 年澳大利亚糖尿病、肥胖和生活方式（AusDiab）研究中，对 2761 名女性和 2103 名年龄≥30 岁（平均年龄 54 岁）、无临床诊断糖尿病的成年人进行了腰围、BMI、静息血压、甘油三酯、高密度脂蛋白胆固醇、空腹和 2 小时餐后血糖以及空腹胰岛素测量。多元线性回归分析检查了久坐时间和看电视时间（每天小时数）与这些生物标志物之间的关联，同时调整了潜在的混杂变量。
对于女性和男性，久坐时间与腰围、BMI、收缩压、空腹甘油三酯、高密度脂蛋白胆固醇、2 小时餐后血糖和空腹胰岛素呈负相关（均 P<0.05），但与空腹血糖和舒张压（仅男性）无关。除了女性的高密度脂蛋白胆固醇和收缩压外，这些关联在进一步调整腰围后仍然显著。看电视时间与女性的所有代谢指标以及男性的除高密度脂蛋白胆固醇和血压以外的所有指标均呈负相关。仅在调整腰围后，空腹胰岛素和血糖（仅男性）仍与看电视时间呈负相关。
在女性和男性中，久坐时间和看电视时间与心血管代谢风险生物标志物呈负相关，久坐时间在两性中具有更一致的关联，且与中心性肥胖无关。旨在减少久坐时间的预防措施应同时关注非休闲和休闲时间领域。
