Department of Pediatrics, Dokkyo University School of Medicine, Tochigi, Japan.
Allergol Int. 2010 Dec;59(4):375-80. doi: 10.2332/allergolint.09-OA-0165. Epub 2010 Sep 25.
Creola bodies (CrBs) in the sputum are an indicator of respiratory epithelial damage and appear specifically in bronchial asthma. We studied the presence and clinical significance of CrBs in infants with respiratory syncytial virus (RSV) bronchiolitis contributing to the development of asthma.
Aspirated sputum samples were collected from 33 infants admitted with acute RSV bronchiolitis. The samples were then examined for the presence (or absence) of CrBs and classified into the RSV-CrB group and RSV-non-CrB group. Eosinophil cationic protein (ECP) and neutrophil elastase (NE) concentrations in the sputum were compared between the two groups. History of wheeze and asthma was collected at 2 years and 5 years after their discharge from hospital.
CrBs were detected in 23 of the 33 subjects (69.7%). No significant difference in the ECP and the NE concentration were observed between the RSV-CrB group and RSV-non-CrB group. A significant relationship was observed between CrBs detected with RSV bronchiolitis and the development of recurrent wheezing and asthma (after 2 years: relative risk [RR], 3.09; p = 0.002; after 5 years: RR 7.00; p = 0.019).
These findings suggest that a high rate of CrBs in the sputum is present in infants with RSV bronchiolitis, and notably the CrBs are associated with the progression to recurrent wheezing and asthma.
痰中的 Creola 体（CrBs）是呼吸上皮损伤的指标，特别是在支气管哮喘中出现。我们研究了导致哮喘发展的呼吸道合胞病毒（RSV）细支气管炎婴儿中 CrBs 的存在及其临床意义。
从 33 名因急性 RSV 细支气管炎入院的婴儿中采集抽吸痰样本。然后检查样本中是否存在（或不存在）CrBs，并将其分为 RSV-CrB 组和 RSV-non-CrB 组。比较两组痰中嗜酸性粒细胞阳离子蛋白（ECP）和中性粒细胞弹性蛋白酶（NE）的浓度。在出院后 2 年和 5 年收集喘息和哮喘的病史。
在 33 名受试者中，有 23 名（69.7%）检测到 CrBs。RSV-CrB 组和 RSV-non-CrB 组之间 ECP 和 NE 浓度无显著差异。在 RSV 细支气管炎中检测到的 CrBs 与反复喘息和哮喘的发展之间存在显著关系（2 年后：相对风险 [RR]，3.09；p = 0.002；5 年后：RR 7.00；p = 0.019）。
这些发现表明，在 RSV 细支气管炎婴儿中，痰中 CrBs 的检出率较高，尤其是 CrBs 与反复喘息和哮喘的进展有关。
