Department of Internal Medicine, University of Alabama at Birmingham, USA.
Am J Hypertens. 2011 Feb;24(2):194-9. doi: 10.1038/ajh.2010.204. Epub 2010 Sep 23.
There are few available data on the epidemiology of prehypertension (preHTN). To determine racial, clinical, and demographic differences in the prevalence of preHTN and its cross-sectional association with vascular risk factors.
Cross-sectional analysis of 5,553 prehypertensives, 20,351 hypertensive's, and 4,246 nonhypertensive participants (age ≥45), from a population-based national cohort study (REasons for Geographic And Racial Differences in Stroke (REGARDS) total population 30,239, of whom 30,150 had adequate blood pressure (BP) measurements) enrolled from January 2003-October 2007 with oversampling from the southeastern stroke belt, and black individuals. Baseline data were collected using a combination of telephone interview and in-home evaluation. preHTN was defined according to The Seventh Report of the Joint national Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure (JNC 7) guidelines.
The prevalence of preHTN was associated with age and black race (62.9% in blacks compared to 54.1% in whites). A higher prevalence of preHTN was observed in obese individuals, self-reported heart disease; and, those with elevated high-sensitivity C reactive protein (hsCRP), diabetes, and microalbuminuria compared to those without these factors. Heavy alcohol consumption in white participants was associated with increased odds of preHTN (odds ratio (OR) = 1.32) but was even greater in black participants (OR = 2.27).
The prevalence of preHTN increased by age and African-American race. In addition, a higher prevalence of preHTN was observed with elevated hsCRP, diabetes, microalbuminuria, and those with heavy alcohol consumption compared to those without these factors.
关于轻度高血压（preHTN）的流行病学数据很少。本研究旨在确定种族、临床和人口统计学方面的差异与轻度高血压的患病率，以及其与血管危险因素的横断面关联。
对来自人群为基础的全国性队列研究（REasons for Geographic And Racial Differences in Stroke [REGARDS] 总人群 30239 人，其中 30150 人有足够的血压（BP）测量值）的 5553 例轻度高血压患者、20351 例高血压患者和 4246 例非高血压患者（年龄≥45 岁）进行横断面分析。该研究于 2003 年 1 月至 2007 年 10 月进行登记，通过东南部中风带和黑人的抽样进行了超额抽样。采用电话访谈和家庭评估相结合的方法收集基线数据。根据第七次联合国家委员会预防、检测、评估和治疗高血压（JNC 7）指南，将轻度高血压定义为。
轻度高血压的患病率与年龄和黑人种族有关（黑人中的患病率为 62.9%，白人中的患病率为 54.1%）。与没有这些因素的患者相比，肥胖、自述心脏病和 hsCRP 升高、糖尿病和微量白蛋白尿的患者中，轻度高血压的患病率更高。与白人参与者相比，白人参与者的大量饮酒与轻度高血压的发生几率增加有关（比值比（OR）=1.32），而黑人参与者的比值比（OR）=2.27）更高。
轻度高血压的患病率随年龄和非裔美国人种族而增加。此外，与没有这些因素的患者相比，hsCRP、糖尿病、微量白蛋白尿和大量饮酒的患者中，轻度高血压的患病率更高。
