Institute of Physiological Chemistry and Pathobiochemistry, University of Münster, 48149 Münster, Germany.
Nat Rev Immunol. 2010 Oct;10(10):712-23. doi: 10.1038/nri2852.
The advent of in situ immunology and intravital analyses of leukocyte movement in tissues has drawn attention to the previously neglected extracellular matrix (ECM) and its role in modulating immune cell behaviour in inflamed tissues. The ECM exists in different biochemical and structural forms; both their individual components and three-dimensional ultrastructure impart specific signals to cells that modulate basic functions that are important for the early steps in inflammation, such as immune cell migration into inflamed tissues and immune cell differentiation. In chronically inflamed tissues, aberrant ECM expression and fragments of the ECM that are derived from tissue-remodelling processes can influence immune cell activation and survival, thereby actively contributing to immune responses at these sites.
原位免疫和白细胞在组织中迁移的活体分析的出现引起了人们对先前被忽视的细胞外基质（ECM）及其在调节炎症组织中免疫细胞行为中的作用的关注。ECM 存在于不同的生化和结构形式中；它们的单个成分和三维超微结构都向细胞传递特定的信号，调节对炎症早期步骤很重要的基本功能，如免疫细胞迁移到炎症组织中和免疫细胞分化。在慢性炎症组织中，细胞外基质的异常表达和来源于组织重塑过程的细胞外基质片段会影响免疫细胞的激活和存活，从而积极促进这些部位的免疫反应。
