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When to start antiretroviral therapy in resource-limited settings.在资源有限的环境中何时开始抗逆转录病毒治疗。
Ann Intern Med. 2009 Aug 4;151(3):157-66. doi: 10.7326/0003-4819-151-3-200908040-00138. Epub 2009 Jul 20.
2
HIV testing rates and outcomes in a South African community, 2001-2006: implications for expanded screening policies.2001 - 2006年南非某社区的艾滋病毒检测率及结果:对扩大筛查政策的启示
J Acquir Immune Defic Syndr. 2009 Jul 1;51(3):310-6. doi: 10.1097/qai.0b013e3181a248e6.
3
HIV testing, human rights, and global AIDS policy: exceptionalism and its discontents.艾滋病毒检测、人权与全球艾滋病政策:例外主义及其不满情绪
J Health Polit Policy Law. 2009 Jun;34(3):301-23. doi: 10.1215/03616878-2009-002.
4
Timing of initiation of antiretroviral therapy in AIDS-free HIV-1-infected patients: a collaborative analysis of 18 HIV cohort studies.未患艾滋病的HIV-1感染患者开始抗逆转录病毒治疗的时机:18项HIV队列研究的协作分析
Lancet. 2009 Apr 18;373(9672):1352-63. doi: 10.1016/S0140-6736(09)60612-7. Epub 2009 Apr 8.
5
Scaling up antiretroviral therapy in South Africa: the impact of speed on survival.扩大南非抗逆转录病毒疗法的规模:速度对生存率的影响。
J Infect Dis. 2008 May 1;197(9):1324-32. doi: 10.1086/587184.
6
Routine offer of antenatal HIV testing ("opt-out" approach) to prevent mother-to-child transmission of HIV in urban Zimbabwe.在津巴布韦城市地区采用常规提供产前艾滋病毒检测(“选择退出”方法)来预防艾滋病毒母婴传播。
Bull World Health Organ. 2007 Nov;85(11):843-50. doi: 10.2471/blt.06.035188.
7
Successful introduction of routine opt-out HIV testing in antenatal care in Botswana.在博茨瓦纳成功将常规的艾滋病病毒(HIV)不拒绝检测引入产前护理。
J Acquir Immune Defic Syndr. 2007 May 1;45(1):102-7. doi: 10.1097/QAI.0b013e318047df88.
8
Field adherence to highly active antiretroviral therapy in HIV-infected adults in Abidjan, Côte d'Ivoire.科特迪瓦阿比让地区HIV感染成人对高效抗逆转录病毒疗法的现场依从性
J Acquir Immune Defic Syndr. 2007 Jul 1;45(3):355-8. doi: 10.1097/QAI.0b013e31805d8ad0.
9
The case for expanding access to highly active antiretroviral therapy to curb the growth of the HIV epidemic.扩大高效抗逆转录病毒疗法的可及性以遏制艾滋病毒疫情增长的理由。
Lancet. 2006 Aug 5;368(9534):531-6. doi: 10.1016/S0140-6736(06)69162-9.
10
Routine HIV testing in Botswana: a population-based study on attitudes, practices, and human rights concerns.博茨瓦纳的常规艾滋病毒检测:一项基于人群的关于态度、做法和人权问题的研究。
PLoS Med. 2006 Jul;3(7):e261. doi: 10.1371/journal.pmed.0030261.

重新思考艾滋病例外论:撒哈拉以南非洲地区选择退出的 HIV 检测的伦理问题。

Rethinking HIV exceptionalism: the ethics of opt-out HIV testing in sub-Saharan Africa.

机构信息

Harvard Medical School, Boston, MA 02115, United States of America.

出版信息

Bull World Health Organ. 2010 Sep 1;88(9):703-8. doi: 10.2471/BLT.09.073049. Epub 2010 Jun 25.

DOI:10.2471/BLT.09.073049
PMID:20865076
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2930364/
Abstract

Opt-out testing for the human immunodeficiency virus (HIV) incorporates testing as a routine part of health care for all patients unless they refuse. The ethics of this approach to testing in sub-Saharan Africa is a source of controversy. Opt-out HIV testing is expected to improve survival by increasing case detection and thus linking more HIV-infected people to earlier treatment, provided there is effective patient follow-up and programme sustainability. At the population level, these benefits will likely outweigh the potential negative consequences of individuals experiencing HIV-related stigma. These justifications appeal to consequentialist moral theories that the acceptability of an action depends upon its outcomes. On the other hand, liberal moral theories state that the autonomy of individuals should always be protected unless restricting autonomy is necessary to protect the welfare of others. Opt-out consent may restrict autonomy and it is unclear whether it would benefit people other than those being tested. Yet, the doctrine of libertarian paternalism proposes that it is justifiable and desirable to use unobtrusive mechanisms to help individuals make choices to maximize their own welfare. Central to this idea are the premises featured by supporters of opt-out consent that individuals will not always make the best choices for their own welfare but they may be influenced to do so in ways that will not compromise their freedom of choice. Also important is the premise that all policies inevitably exert some such influence: opt-in consent encourages test refusal just as opt-out consent encourages acceptance. Based on these premises, opt-out testing may be an effective and ethically acceptable policy response to Africa's HIV epidemic.

摘要

艾滋病毒(HIV)的选择退出检测将检测作为所有患者常规医疗保健的一部分,除非他们拒绝。这种在撒哈拉以南非洲进行检测的方法的伦理学是争议的来源。选择退出 HIV 检测有望通过提高病例检出率来提高生存率,从而使更多感染 HIV 的人更早接受治疗,前提是有有效的患者随访和项目可持续性。在人群层面,这些好处可能超过个人经历 HIV 相关耻辱的潜在负面影响。这些理由诉诸于后果主义道德理论,即行动的可接受性取决于其结果。另一方面,自由意志主义道德理论规定,个人的自主权应始终得到保护,除非限制自主权是保护他人福利所必需的。选择退出同意可能会限制自主权,而且尚不清楚它是否会使除受检者以外的其他人受益。然而,自由意志主义家长式作风的学说提出,使用不显眼的机制来帮助个人做出选择以最大程度地提高自身福利是合理且可取的。这一理念的核心是选择退出同意的支持者所提出的前提,即个人并不总是为自己的福利做出最佳选择,但可以通过不会损害他们选择自由的方式来影响他们做出这样的选择。同样重要的是这样一个前提,即所有政策都不可避免地施加了这种影响:选择加入同意鼓励拒绝检测,就像选择退出同意鼓励接受检测一样。基于这些前提,选择退出检测可能是非洲艾滋病毒流行的有效和道德上可接受的政策反应。