Department of Pediatrics, Clinical Sciences Lund, Lund University, Lund, Sweden.
Semin Thromb Hemost. 2010 Sep;36(6):575-85. doi: 10.1055/s-0030-1262879. Epub 2010 Sep 23.
The typical form of hemolytic uremic syndrome (HUS) is associated with enterohemorrhagic ESCHERICHIA COLI (EHEC) infection. The disease process is initiated and perpetuated by interactions between the pathogen or its virulence factors and host cells, as well as the host response. During EHEC-associated HUS, alterations occurring at the intestinal mucosal barrier and in the circulation, as well as on endothelial cells and other target-organ cells, lead to cell activation and/or cytotoxicity, and trigger a prothrombotic state. This review summarizes current knowledge regarding the interactions of the pathogen and its virulence factors with cells in the intestine, bloodstream, kidney, and brain. Mechanisms of bacterial colonization, toxin circulation, and induction of target organ damage are discussed.
典型的溶血尿毒综合征（HUS）与肠出血性大肠杆菌（EHEC）感染有关。病原体或其毒力因子与宿主细胞以及宿主反应之间的相互作用引发并延续了疾病过程。在 EHEC 相关的 HUS 中，发生在肠黏膜屏障和循环系统以及内皮细胞和其他靶器官细胞上的改变导致细胞激活和/或细胞毒性，并引发血栓前状态。这篇综述总结了目前关于病原体及其毒力因子与肠道、血液、肾脏和大脑细胞相互作用的知识。讨论了细菌定植、毒素循环和诱导靶器官损伤的机制。
