Department of Pediatrics, Medical University of Innsbruck, Innsbruck, Austria.
Semin Thromb Hemost. 2010 Sep;36(6):586-93. doi: 10.1055/s-0030-1262880. Epub 2010 Sep 23.
Infection by enterohemorrhagic ESCHERICHIA COLI (EHEC) is the most frequent cause of hemolytic uremic syndrome (HUS) in childhood. During a 6-year period, all patients with the clinical diagnosis of HUS were registered in a prospective multicenter study in Austria and Germany. EHEC O26:H11 was the second most frequent detected serotype, accounting for 15.4% of all EHEC isolates. The presence of EHEC O26:H11 was significantly associated with young age at the disease onset ( P < 0.001). Patients infected with this serotype were not different in their clinical presentation than those infected with other serotypes. This study underlines the importance of EHEC serotypes other than O157 in the etiology of HUS and emphasizes the importance of implementation of appropriate diagnostic methods to identify the whole spectrum of EHEC associated with HUS.
肠出血性大肠杆菌（EHEC）感染是儿童溶血性尿毒症综合征（HUS）最常见的病因。在 6 年期间，奥地利和德国的一项前瞻性多中心研究中登记了所有临床诊断为 HUS 的患者。EHEC O26：H11 是检测到的第二常见血清型，占所有 EHEC 分离株的 15.4%。EHEC O26：H11 的存在与疾病发病时的年龄较小显著相关（P<0.001）。感染该血清型的患者与感染其他血清型的患者在临床表现上没有差异。本研究强调了除 O157 以外的其他 EHEC 血清型在 HUS 病因学中的重要性，并强调了实施适当诊断方法以识别与 HUS 相关的整个 EHEC 谱的重要性。
