Leibniz-Institut für Katalyse e.V. an der Universität Rostock, Albert-Einstein-Strasse 29a, 18059 Rostock, Germany.
J Am Chem Soc. 2010 Oct 20;132(41):14596-602. doi: 10.1021/ja1059922.
The first general palladium-catalyzed carbonylative vinylation of aryl halides with olefins in the presence of CO has been developed. Applying a catalyst system consisting of (cinnamyl)PdCl and bulky imidazolyl-phosphine ligand L1 allows for the efficient and selective synthesis of α,β-unsaturated ketones under mild reaction conditions. Starting from easily available aryl halides and olefins, versatile building blocks can be prepared in a straightforward manner. The generality and functional group tolerance of this novel protocol is demonstrated.
首次在一氧化碳存在的条件下，发展了芳基卤化物与烯烃的钯催化羰基烯丙基化反应。应用由[(肉桂基)PdCl2]2和大位阻咪唑基膦配体 L1 组成的催化剂体系，可以在温和的反应条件下高效和选择性地合成α,β-不饱和酮。该方法以易得的芳基卤化物和烯烃为起始原料，可以直接制备多功能砌块。该新方法具有广泛的适用性和官能团容忍性。
