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麻风病患者尿液和血清中麻风杆菌35 kD决定簇抗体的检测

Detection of antibodies to 35 kD determinant of M. leprae in urine and serum of leprosy patients.

作者信息

Patil S, Dwivedi P, Kiran K, Singh K, Sengupta U

机构信息

Dept. Immunology, Central JALMA Institute for Leprosy, Taj Ganj, Agra, U.P., India.

出版信息

Acta Leprol. 1990;7(2):139-43.

PMID:1699385
Abstract

Urine and serum samples from 67 subjects comprising 55 active cases of different types of leprosy and 12 normal controls were subjected to monoclonal antibody based urine antibody competition test (UACT) and serum antibody competition test (SACT) respectively. It was possible to demonstrate M. leprae specific antibodies in the urine of 50% of the seropositive subjects. Urine antibody positivity was observed to the extent of 52% in BL/LL subjects, 50% in BB and 43% in TT/BT types of leprosy.

摘要

对67名受试者的尿液和血清样本进行了检测,其中包括55例不同类型麻风病的活动期病例和12名正常对照,分别进行了基于单克隆抗体的尿液抗体竞争试验(UACT)和血清抗体竞争试验(SACT)。在50%的血清阳性受试者尿液中能够检测到麻风杆菌特异性抗体。在瘤型/界线类偏瘤型(BL/LL)麻风病患者中,尿液抗体阳性率为52%;在中间界线类(BB)患者中为50%;在结核样型/界线类偏结核样型(TT/BT)麻风病患者中为43%。

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