Osipova T V, Bukhman V M, Belianchikova N I, Svet-Moldavskiĭ G Ia
Biull Eksp Biol Med. 1978 Mar;85(3):346-9.
Hemangiopericytoma growth in syngeneic male mice F1 (CBA X C57BL/bj) led to regular hemopoietic changes: an increase in the spleen weight, spleen cell count, in the number of colony-forming units (CFU). It also induced augmentation of myelopoiesis in the spleen and leukocytosis with a sharp increase of segmented granulocytes in the circulating blood characterized as the "leukemoid reaction" syndrome. The latter occurred even when the tumour cells were transplanted into the splenectomized host. Although less marked, this leukemoid reaction was also noted in advanced hepatoma transplanted to syngeneic male mice F1 (CBA X C57BL/6j). No leukemoid reaction was observed in these mice after grafting syngeneic strain of urinary bladder carcinoma.
同基因雄性F1代小鼠（CBA×C57BL/bj）体内的血管外皮细胞瘤生长导致了正常的造血变化：脾脏重量增加、脾细胞数量增多、集落形成单位（CFU）数量增加。它还诱导脾脏中骨髓生成增加以及白细胞增多，循环血液中分段粒细胞急剧增加，表现为“类白血病反应”综合征。即使将肿瘤细胞移植到脾切除的宿主中，后者也会出现。虽然不太明显，但在移植到同基因雄性F1代小鼠（CBA×C57BL/6j）体内的晚期肝癌中也观察到了这种类白血病反应。将同基因膀胱癌细胞株移植到这些小鼠体内后，未观察到类白血病反应。
