[肿瘤细胞膜特异性移植抗原的热敏感性]
[Thermal sensitivity of specific transplantation antigens of the tumor-cell membrane].
作者信息
Kliuchareva T E
出版信息
Biull Eksp Biol Med. 1978 Mar;85(3):351-3.
PMID:208683
Abstract
Study of temperature-sensitivity of the tumour specific transplantation antigen (TSTA) on the cell membrane of SV40-induced tumours and spontaneous hepatoma of inbred Syrian hamsters, as well as in the monkey cells infected in vitro with SV40 virus (ts-mutant) demonstrated high thermolability of TSTA. Heating such cells at 56 degrees C for 30-60 min led to complete loss of their immunogenic activity. Moreover, in the animals immunized with heated tumour cells the test-tumour cell growth was regularly enhanced.
摘要
对叙利亚近交系仓鼠的SV40诱导肿瘤和自发性肝癌细胞膜上肿瘤特异性移植抗原（TSTA）的温度敏感性进行研究，以及对体外感染SV40病毒（ts突变体）的猴细胞进行研究，结果表明TSTA具有高热敏感性。将这些细胞在56℃加热30 - 60分钟会导致其免疫原性活性完全丧失。此外，在用加热后的肿瘤细胞免疫的动物中，测试肿瘤细胞的生长会规律性增强。
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