Nanke Yuki, Yago Toru, Kotake Shigeru
Institute of Rheumatology, Tokyo Women's Medical University, 10-22 Kawada-cho, Shinjuku-ku, Tokyo 162-0054, Japan.
J Clin Med. 2017 Jul 21;6(7):74. doi: 10.3390/jcm6070074.
Behcet's disease (BD) is a polysymptomatic and recurrent systemic vasculitis with a chronic course and unknown cause. The pathogenesis of BD has not been fully elucidated; however, BD has been considered to be a typical Th1-mediated inflammatory disease, characterized by elevated levels of Th1 cytokines such as IFN-γ, IL-2, and TNF-α. Recently, some studies reported that Th17-associated cytokines were increased in BD; thus, Th17 cells and the IL17/IL23 pathway may play important roles in the pathogenesis of BD. In this chapter, we focus on the pathogenic role of Th17 cells in BD.
白塞病(BD)是一种多症状、复发性的全身性血管炎,病程慢性且病因不明。BD的发病机制尚未完全阐明;然而,BD一直被认为是一种典型的Th1介导的炎症性疾病,其特征是Th1细胞因子如IFN-γ、IL-2和TNF-α水平升高。最近,一些研究报道BD中Th17相关细胞因子增加;因此,Th17细胞和IL17/IL23途径可能在BD的发病机制中起重要作用。在本章中,我们重点关注Th17细胞在BD中的致病作用。