Department of Computer Science and Engineering, The Chinese University of Hong Kong, Shatin, Hong Kong.
Prog Biophys Mol Biol. 2010 Dec;103(2-3):252-61. doi: 10.1016/j.pbiomolbio.2010.09.003. Epub 2010 Sep 22.
A meshless rheological model is proposed for medical simulation of vascular procedures. Due to the complexity of rheologic models involved in endovascular simulations, delivering a high level of interactivity with realistic biomechanical feedback is still a challenge. In this paper, we propose a particle-based rheologic modeling method for virtual catheterisation training applications. The effect of blood rheology has been simulated through a smoothed particle hydrodynamics (SPH) formulation of non-Newtonian flow. By modeling vessel wall structure as virtual particles, a pure Lagrange particle formulation for fluid-structure interaction (FSI) is purposed for modeling the blood-vessel interaction. We further propose a flow-related thrombus (clot) formation-dissolution model based on our fluid-solid interaction framework. A physics processing API (PhysX) friendly implementation is proposed for incorporating the rheological properties of blood and vessel wall into our framework. Results have demonstrated the feasibility of employing our proposed meshfree framework in simulating blood-vessel interaction and clotting behaviors which are essential to endovascular simulations. Having benefited from the elegant formulation of Lagrangian particle interaction, interactive framerates of the simulation can be maintained under hardware-acceleration.
提出了一种用于血管手术医学模拟的无网格流变学模型。由于血管内模拟中涉及的流变学模型的复杂性，提供具有真实生物力学反馈的高度交互性仍然是一个挑战。在本文中，我们提出了一种基于粒子的流变学建模方法，用于虚拟导管培训应用。通过非牛顿流的平滑粒子流体动力学 (SPH) 公式模拟了血液流变学的影响。通过将血管壁结构建模为虚拟粒子，提出了一种用于模拟血液-血管相互作用的纯拉格朗日粒子流固耦合 (FSI) 公式。我们进一步提出了一种基于我们的流固相互作用框架的与流动相关的血栓（凝块）形成-溶解模型。提出了一种物理处理 API（PhysX）友好的实现方法，将血液和血管壁的流变特性纳入我们的框架中。结果表明，在模拟血管相互作用和血栓形成行为方面，我们提出的无网格框架具有可行性，这对于血管内模拟至关重要。受益于拉格朗日粒子相互作用的优雅公式，在硬件加速下可以保持模拟的交互帧率。
