Departamento de Salud, Universidad Iberoamericana, Prolongación Paseo de la Reforma 880, Ciudad de México, Mexico.
Pharmacol Res. 2011 Jan;63(1):44-50. doi: 10.1016/j.phrs.2010.09.003. Epub 2010 Sep 22.
The aim of this study was to investigate the effects of astaxanthin-enriched diet on blood pressure, cardiac hypertrophy, both vascular structure and function and superoxide (()O(2-)) production in spontaneously hypertensive rats (SHR). Twelve-week-old SHR were treated for 8 weeks with an astaxanthin-enriched diet (75 or 200mg/kg body weight per day). Systolic blood pressure was monitorized periodically during the study by the tail cuff method. At the end of the study animals were sacrificed and heart, kidneys and aorta were removed. Left ventricular weight/body weight ratio was used as left ventricular hypertrophy index (LVH). Vascular function and structure were studied in conductance (aortic rings) and resistance (renal vascular bed) arteries. Also ()O(2-) production was evaluated by lucigenin-enhanced chemiluminescence. Systolic blood pressure was lower in astaxanthin-treated groups than the control group from the first week of treatment, and LVH was significantly reduced. Astaxanthin improved endothelial function on resistance arteries, but had no effect on aorta. These effects were accompanied by a decrease in oxidative stress and improvements in NO bioavailability. Taken together, these results show that diet supplemented with astaxanthin has beneficial effects on hypertension, by decreasing blood pressure values, improving cardiovascular remodeling and oxidative stress.
本研究旨在探讨富含虾青素饮食对自发性高血压大鼠（SHR）血压、心脏肥大、血管结构和功能以及超氧阴离子（(）O(2-))产生的影响。12 周龄的 SHR 用富含虾青素的饮食（每天 75 或 200mg/kg 体重）治疗 8 周。通过尾套法在研究期间定期监测收缩压。研究结束时，处死动物并取出心脏、肾脏和主动脉。左心室重量/体重比用作左心室肥厚指数（LVH）。在导纳（主动脉环）和阻力（肾血管床）动脉中研究血管功能和结构。还通过发光增强化学发光法评估（()O(2-))的产生。从治疗的第一周开始，虾青素治疗组的收缩压低于对照组，LVH 显著降低。虾青素改善了阻力动脉的内皮功能，但对主动脉没有影响。这些作用伴随着氧化应激的降低和 NO 生物利用度的提高。总之，这些结果表明，富含虾青素的饮食对高血压有有益的影响，可降低血压值、改善心血管重构和氧化应激。
