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J Am Dent Assoc. 2009 Oct;140(10):1259-65. doi: 10.14219/jada.archive.2009.0049.
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Bisphosphonate-associated osteonecrosis of the jaw: a key role of inflammation?双膦酸盐相关颌骨坏死：炎症起关键作用？
Bone. 2009 Nov;45(5):843-52. doi: 10.1016/j.bone.2009.07.011. Epub 2009 Jul 22.
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Higher bone matrix density exists in only a subset of patients with bisphosphonate-related osteonecrosis of the jaw.较高的骨基质密度仅存在于双膦酸盐相关颌骨坏死患者的一个亚组中。
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5
The pathogenesis of bisphosphonate-related osteonecrosis of the jaw: so many hypotheses, so few data.双膦酸盐相关颌骨坏死的发病机制：假说众多，数据匮乏。
J Oral Maxillofac Surg. 2009 May;67(5 Suppl):61-70. doi: 10.1016/j.joms.2009.01.007.
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Frequency and risk factors associated with osteonecrosis of the jaw in cancer patients treated with intravenous bisphosphonates.接受静脉注射双膦酸盐治疗的癌症患者颌骨坏死的发生率及相关危险因素。
J Bone Miner Res. 2008 Jun;23(6):826-36. doi: 10.1359/jbmr.080205.
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Identification of microbial biofilms in osteonecrosis of the jaws secondary to bisphosphonate therapy.双膦酸盐治疗继发颌骨坏死中微生物生物膜的鉴定
J Oral Maxillofac Surg. 2008 Apr;66(4):767-75. doi: 10.1016/j.joms.2007.11.035.
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颌骨骨坏死持续时间与死骨组织形态之间缺乏相关性：这对该病症的启示以及对未来研究的意义。

Lack of correlation between duration of osteonecrosis of the jaw and sequestra tissue morphology: what it tells us about the condition and what it means for future studies.

作者信息

Allen Matthew R, Pandya Binal, Ruggiero Salvatore L

机构信息

Department of Anatomy and Cell Biology, Indiana University School of Medicine, Indianapolis, IN 46202, USA.

出版信息

J Oral Maxillofac Surg. 2010 Nov;68(11):2730-4. doi: 10.1016/j.joms.2010.05.090.

DOI:10.1016/j.joms.2010.05.090
PMID:20869151
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2963684/
Abstract

PURPOSE

More studies have begun to investigate properties of tissue obtained from patients with osteonecrosis of the jaw (ONJ). Because of the relatively low incidence of ONJ, these studies necessitate the use of specimens from patients who have had ONJ for various durations. The goal of this study was to determine if properties, specifically bone morphology assessed by microcomputed tomography, were influenced by the duration of ONJ.

MATERIALS AND METHODS

Sequestra from 31 patients with confirmed ONJ for 3 weeks to 42 months before obtaining the tissue were scanned using microcomputed tomography to determine bone volume/tissue volume and bone surface/tissue volume.

RESULTS

There was no significant correlation between the sequestra bone morphology (bone volume/tissue volume or bone surface/tissue volume) and the duration of ONJ.

CONCLUSION

The findings indicated that studies should not be concerned about assessing tissue properties from patients who have had ONJ for different durations. In addition, the lack of difference in morphology with continued duration of ONJ suggests that most changes to bone tissue occur early in the disease progression.

摘要

目的

越来越多的研究开始探究从颌骨坏死（ONJ）患者获取的组织的特性。由于ONJ的发病率相对较低，这些研究需要使用来自患有不同病程ONJ患者的标本。本研究的目的是确定特性，特别是通过微型计算机断层扫描评估的骨形态，是否受ONJ病程的影响。

材料与方法

对31例确诊为ONJ的患者在获取组织前3周至42个月的死骨进行微型计算机断层扫描，以确定骨体积/组织体积和骨表面积/组织体积。

结果

死骨的骨形态（骨体积/组织体积或骨表面积/组织体积）与ONJ病程之间无显著相关性。

结论

研究结果表明，研究不应担心评估不同病程ONJ患者的组织特性。此外，随着ONJ病程的延长，形态学上缺乏差异表明骨组织的大多数变化发生在疾病进展的早期。