Laboratory of Experimental Psychology, Katholieke Universiteit Leuven, Leuven, Belgium.
Neuroimage. 2011 Jan 15;54(2):824-35. doi: 10.1016/j.neuroimage.2010.09.041. Epub 2010 Sep 30.
Simultaneous EEG-fMRI measurements can combine the high spatial resolution of fMRI with the high temporal resolution of EEG. Therefore, we applied this approach to the study of peripheral vision. More specifically, we presented visual field quadrant fragments of checkerboards and a full central checkerboard in a simple detection task. A technique called "integration-by-prediction" was used to integrate EEG and fMRI data. In particular, we used vectors of single-trial ERP amplitude differences between left and right occipital electrodes as regressors in an ERP-informed fMRI analysis. The amplitude differences for the regressors were measured at the latencies of the visual P1 and N1 components. Our results indicated that the traditional event-related fMRI analysis revealed mostly activations in the vicinity of the primary visual cortex and in the ventral visual stream, while both P1 and N1 regressors revealed activation of areas in the temporo-parietal junction. We conclude that simultaneous EEG-fMRI in a spatial detection task can separate visual processing at 100-200 ms from stimulus onset from the rest of the information processing in the brain.
同时进行 EEG-fMRI 测量可以将 fMRI 的高空间分辨率与 EEG 的高时间分辨率结合起来。因此，我们将这种方法应用于周边视觉研究。更具体地说，我们在一个简单的检测任务中呈现了棋盘的视场象限片段和一个完整的中央棋盘。一种名为“预测积分”的技术被用于整合 EEG 和 fMRI 数据。特别是，我们使用左、右枕部电极之间单次试验 ERP 幅度差异的向量作为 ERP 知情 fMRI 分析中的回归量。回归量的幅度差异是在视觉 P1 和 N1 成分的潜伏期测量的。我们的结果表明，传统的事件相关 fMRI 分析主要揭示了初级视觉皮层及其周围区域和腹侧视觉流中的激活，而 P1 和 N1 回归量都揭示了颞顶联合区的激活。我们得出结论，在空间检测任务中同时进行 EEG-fMRI 可以将刺激开始后 100-200 毫秒的视觉处理与大脑中其余的信息处理区分开来。
