Department of Obstetrics and Gynecology, McGill University, Montreal, Quebec, Canada.
Fertil Steril. 2011 Feb;95(2):663-6. doi: 10.1016/j.fertnstert.2010.08.047. Epub 2010 Sep 25.
To produce age-related normograms for antral follicle count in an infertile population without polycystic ovaries.
Retrospective cohort analysis.
University teaching center.
PATIENT(S): Eighteen hundred sixty-six infertile patients.
INTERVENTION(S): Baseline transvaginal ultrasound examination between days 2 and 4 of the menstrual cycle.
MAIN OUTCOME MEASURE(S): Correlation between age and different percentiles of antral follicle count.
RESULT(S): The age-related normogram for the 3rd, 10th, 25th, 50th, 75th, 90th, and 97th percentile of antral follicle count showed a biphasic mode of antral follicle count decline with two different rates of antral follicle count loss: a steep-slope phase (high rate of antral follicle count loss) and a moderate-slope phase (restrained rate of antral follicle count losses). In the low antral follicle count percentiles (3rd, 10th, 25th), the phase of high loss rate of follicles preceded the phase of slow loss rate, whereas in the high antral follicle count percentiles (75th, 90th, 97th) the opposite was found.
CONCLUSION(S): Age-related normograms in infertile women without polycystic ovaries demonstrate a biphasic pattern of decreased antral follicles. These normograms could provide a reference guide for the clinician in consulting with women with infertility. However, future validation with longitudinal data is still needed.
为无多囊卵巢的不孕人群制定与年龄相关的窦卵泡计数正常图表。
回顾性队列分析。
大学教学中心。
1866 名不孕患者。
月经周期第 2-4 天进行经阴道超声检查。
年龄与不同窦卵泡计数百分位数之间的相关性。
第 3、10、25、50、75、90 和 97 百分位的年龄相关正常图表显示窦卵泡计数下降呈双相模式，具有两种不同的窦卵泡计数损失率：陡峭斜率阶段（高窦卵泡计数损失率）和中度斜率阶段（窦卵泡计数损失率受限制）。在低窦卵泡计数百分位数（第 3、10、25 位）中，卵泡高损失率阶段先于卵泡慢损失率阶段，而在高窦卵泡计数百分位数（第 75、90 和 97 位）中则相反。
无多囊卵巢不孕妇女的年龄相关正常图表显示窦卵泡减少呈双相模式。这些正常图表可以为临床医生咨询不孕女性提供参考指南。然而，仍需要用纵向数据进行进一步验证。
