Division of Cardiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
J Pediatr. 2011 Feb;158(2):208-14.e1. doi: 10.1016/j.jpeds.2010.08.012. Epub 2010 Sep 25.
To evaluate the relationships of adiponectin levels at age 16 years in obese schoolgirls to metabolic syndrome and its components at age 23 years.
Seven-year prospective study of 381 females.
In 144 white and 129 black non-obese 16-year old girls (body mass index < 24.6 kg/m(2)), race-specific median adiponectin levels (white 12 mg/L, black 11) was used to identify paradoxically high adiponectin levels in obese girls. Of 34 white and 74 black obese girls, 12 (35%) and 19 (26%) had paradoxically high adiponectin levels. In these 108 obese girls, adiponectin levels at age 16 years independently predicted high-density lipoprotein cholesterol (positive) and waist (negative), insulin (negative), and glucose (negative) at age 23 years; paradoxically high adiponectin levels at age 16 years was a negative independent predictor for waist, homeostatic model assessment-insulin resistance, and for the number of abnormal components of the metabolic syndrome at age 23 years. In 31 pairs of obese girls with and without paradoxically high adiponectin levels, matched by race and age 16 body mass index, adiponectin levels at age 16 years was a negative predictor for the number of abnormal metabolic syndrome components at age 23 years.
Paradoxically high adiponectin levels in obese 16 year old girls protects against metabolic syndrome and its components at age 23 years.
评估肥胖少女 16 岁时的脂联素水平与 23 岁时代谢综合征及其各组分的关系。
对 381 名女性进行了为期 7 年的前瞻性研究。
在 144 名白人非肥胖和 129 名黑人非肥胖的 16 岁少女（体重指数<24.6kg/m²）中，根据种族特异性的中位脂联素水平（白人 12mg/L，黑人 11），鉴定出肥胖少女中存在的脂联素水平反常升高现象。在 34 名白人肥胖和 74 名黑人肥胖少女中，分别有 12 名（35%）和 19 名（26%）存在脂联素水平反常升高。在这 108 名肥胖少女中，16 岁时的脂联素水平独立预测了 23 岁时高密度脂蛋白胆固醇（正相关）和腰围（负相关）、胰岛素（负相关）和血糖（负相关）；16 岁时的脂联素水平反常升高是 23 岁时腰围、稳态模型评估-胰岛素抵抗和代谢综合征异常组分数量的独立负预测因子。在有和无脂联素水平反常升高的 31 对肥胖少女中，按种族和 16 岁时体重指数进行匹配，16 岁时的脂联素水平是 23 岁时代谢综合征异常组分数量的负预测因子。
肥胖少女 16 岁时的脂联素水平反常升高可预防 23 岁时发生代谢综合征及其各组分。
