Warolin J, Coenen K R, Kantor J L, Whitaker L E, Wang L, Acra S A, Roberts L J, Buchowski M S
Department of Pediatrics, Division of Gastroenterology, Vanderbilt University Medical Center, Nashville, TN, USA.
Pediatr Obes. 2014 Feb;9(1):43-52. doi: 10.1111/j.2047-6310.2012.00135.x. Epub 2013 Jan 7.
What is already known about this subject African Americans are disproportionately affected by obesity and other metabolic risk factors in comparison to White Americans. Increasing prevalence of obesity has been associated with concomitant increases in childhood hypertension, dyslipidaemia and type 2 diabetes. Oxidative stress is associated with obesity in both adults and children. What this study adds Oxidative stress is positively associated with total body fat and truncal fat, but not with body mass index (BMI) or BMI z-score in healthy youth. Oxidative stress is associated with diastolic blood pressure in African American but not in White American healthy youth.
Oxidative stress is elevated in obese youth, but less is known regarding racial disparities in the relationship of oxidative stress with metabolic risk factors.
To determine the relationship between oxidative stress and metabolic risk factors, adiposity, leptin, adiponectin and cardiovascular fitness (VO2PEAK ) in healthy African American and White American youth.
A marker of oxidative stress (F2 -isoprostane), validated markers of metabolic risk factors, fitness and body composition were measured in African American (n = 82) and White American (n = 76) youth (8-17 years old) recruited over a range of BMI percentiles (4th to 99th).
F2 -isoprostane concentration was positively correlated with percentage body fat (r = 0.198) and percentage truncal fat (r = 0.173), but was not different between African American and White American males and females (P = 0.208). African American youth had significantly higher mean systolic and diastolic blood pressure (P = 0.023 and P = 0.011, respectively), body weight, BMI percentile and Tanner stage. After adjusting for gender, age, BMI and Tanner stage, African American youth varied from White Americans in the association of F2 -isoprostane with diastolic blood pressure (P = 0.047), but not with systolic blood pressure, triglycerides, VO2PEAK or homeostatic model assessment for insulin resistance (all P > 0.05).
Oxidative stress, as measured by urinary F2 -isoprostane concentrations, was positively associated with percent body fat and truncal fat in youth. Oxidative stress levels were similar among African American and White American youth. Among markers of the metabolic syndrome, a significant difference between African American and White American youth was demonstrated only in the association of oxidative stress with diastolic blood pressure.
关于该主题已知的情况是，与美国白人相比，非裔美国人受肥胖及其他代谢风险因素的影响比例更高。肥胖患病率的上升与儿童期高血压、血脂异常和2型糖尿病的相应增加有关。氧化应激在成人和儿童中均与肥胖相关。本研究的新增内容：氧化应激与健康青年的全身脂肪和躯干脂肪呈正相关，但与体重指数（BMI）或BMI z评分无关。氧化应激与非裔美国健康青年的舒张压相关，但与美国白人健康青年无关。
肥胖青年的氧化应激水平升高，但关于氧化应激与代谢风险因素关系中的种族差异所知较少。
确定氧化应激与健康的非裔美国和美国白人青年的代谢风险因素、肥胖、瘦素、脂联素及心血管适能（峰值摄氧量）之间的关系。
对招募的处于一系列BMI百分位数（第4至99百分位数）的非裔美国（n = 82）和美国白人（n = 76）青年（8至17岁）测量氧化应激标志物（F2-异前列腺素）、代谢风险因素、适能及身体成分的验证标志物。
F2-异前列腺素浓度与体脂百分比（r = 0.198）和躯干脂肪百分比（r = 0.173）呈正相关，但在非裔美国和美国白人男性及女性之间无差异（P = 0.208）。非裔美国青年的平均收缩压和舒张压显著更高（分别为P = 0.023和P = 0.011），体重、BMI百分位数和坦纳分期也更高。在调整性别、年龄、BMI和坦纳分期后，非裔美国青年在F2-异前列腺素与舒张压的关联方面与美国白人不同（P = 0.047），但与收缩压、甘油三酯、峰值摄氧量或胰岛素抵抗的稳态模型评估均无关（所有P>0.05）。
通过尿F2-异前列腺素浓度测量的氧化应激与青年的体脂百分比和躯干脂肪呈正相关。非裔美国和美国白人青年的氧化应激水平相似。在代谢综合征的标志物中，非裔美国和美国白人青年之间仅在氧化应激与舒张压的关联方面存在显著差异。
