传统抗真菌药物对从尼日利亚临床和环境样本中分离出的伪阿利什霉的体外活性。
In vitro activity of conventional antifungal agents against Scedosporium apiospermum isolates recovered from clinical and environmental samples in Nigeria.
作者信息
Nweze E I, Okafor J I
机构信息
University of Nigeria, Department of Microbiology, Nsukka, Nigeria.
出版信息
Acta Microbiol Immunol Hung. 2010 Sep;57(3):209-14. doi: 10.1556/AMicr.57.2010.3.5.
In vitro susceptibilities of Scedosporium apiospermum isolates recovered from clinical and environmental samples in Nigeria were tested against ten conventional antifungal agents, namely: amphotericin B, nystatin, flucytosine, itraconazole, posaconazole, fluconazole, voriconazole, micafungin, ketoconazole, and terbinafine using the CLSI M38-A broth dilution reference method. The isolates showed varied response/sensitivities to the antifungal agents tested. This is probably the first documented testing of Scedosporium apiospermum isolates from Africa in general and Nigeria in particular against a broad range of conventional antifungal agents.
采用CLSI M38 - A肉汤稀释参考方法，对从尼日利亚临床和环境样本中分离出的裴氏外瓶霉菌株进行了体外药敏试验，受试的十种传统抗真菌药物分别为：两性霉素B、制霉菌素、氟胞嘧啶、伊曲康唑、泊沙康唑、氟康唑、伏立康唑、米卡芬净、酮康唑和特比萘芬。这些菌株对所测试的抗真菌药物表现出不同的反应/敏感性。这可能是首次有文献记载对来自非洲（尤其是尼日利亚）的裴氏外瓶霉菌株进行针对多种传统抗真菌药物的测试。
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