Neonatal Intensive Care Unit, S Orsola-Malpighi General Hospital, University of Bologna, Italy.
Arch Dis Child Fetal Neonatal Ed. 2012 May;97(3):F211-3. doi: 10.1136/adc.2010.183863. Epub 2010 Sep 24.
To study the prevalence of congenital syphilis and its risk factors in Italy.
Prospective study from 1 July 2006 to 30 June 2007. Data on mother-child pairs were collected for every syphilis seropositive mother.
Maternal syphilis seroprevalence at delivery was 0.17%. 207 infants were born to 203 syphilis seropositive mothers. In 25 newborns it was possible to diagnose congenital syphilis (20/100,000 live births). Maternal risk factors included age <20 years, no antenatal care and no adequate treatment. The infected babies were more often preterm or weighed <2000 g at birth.
Many syphilis seropositive mothers were foreign born but the risk of an infected newborn was not higher in foreign-born than in Italian seropositive women. The significant factors were lack of antenatal screening and inadequate maternal treatment.
Syphilis is a re-emerging infection in Italy. Prevention strategies should include antenatal serological tests for all pregnant women and treatment for infected mothers.
研究意大利先天性梅毒的流行情况及其危险因素。
前瞻性研究，时间为 2006 年 7 月 1 日至 2007 年 6 月 30 日。对每例梅毒血清阳性的母亲所生的母婴对子进行数据收集。
分娩时母体梅毒血清阳性率为 0.17%。203 例梅毒血清阳性母亲中共有 207 名婴儿出生。在 25 名新生儿中可以诊断出先天性梅毒（20/100,000 活产儿）。母体危险因素包括年龄<20 岁、无产前保健和未进行适当治疗。感染的婴儿更常早产或出生体重<2000 克。
许多梅毒血清阳性的母亲是外国出生的，但感染新生儿的风险在外国出生的母亲中并不高于意大利血清阳性的母亲。显著的因素是缺乏产前筛查和母亲治疗不足。
梅毒在意大利再次流行。预防策略应包括对所有孕妇进行产前血清学检查，并对感染的母亲进行治疗。
