Division of Gastroenterology and Hepatology, Department of Medicine, Riyadh Military Hospital, Riyadh, Saudi Arabia.
Saudi J Gastroenterol. 2010 Oct-Dec;16(4):299-301. doi: 10.4103/1319-3767.70621.
Hepatic involvement in brucellosis is not uncommon since 10-20% of patient infected with brucella species can have abnormal liver function tests. The usual presentation of brucella hepatitis is in the form of chronic granulomatous hepatitis with mild to moderate elevation of liver enzymes, while acute hepatitis is rare. We report a young patient who presented with acute brucella-induced hepatitis and co-infection with dengue hemorrhagic virus resulting in severe elevation of liver enzymes and absence of granuloma on histology. His mother also simultaneously tested positive for both infections. The patient responded well to anti-brucella therapy with normalization of his liver profile. We discuss, herein, the hepatic involvement of these two infections and discuss the possible serological cross-reactivity between brucella and dengue fever virus.
肝脏受累在布鲁氏菌病中并不少见，因为感染布鲁氏菌的 10-20%的患者可能会出现肝功能异常。布鲁氏菌性肝炎的常见表现为慢性肉芽肿性肝炎，伴有肝酶轻度至中度升高，而急性肝炎则很少见。我们报告了一位年轻患者，他表现为急性布鲁氏菌诱导的肝炎，并合并感染登革热病毒，导致肝酶显著升高，组织学上无肉芽肿。他的母亲也同时检测出这两种感染呈阳性。患者对布鲁氏菌治疗反应良好，肝功能恢复正常。在此，我们讨论了这两种感染的肝脏受累情况，并讨论了布鲁氏菌与登革热病毒之间可能的血清学交叉反应。
