Thiebauld C, Lintermans J, Friob L
Centre de Médecine Avancée, Brussels, Belgium.
Methods Find Exp Clin Pharmacol. 1990 Jul-Aug;12(6):435-41.
Effects of Neurotropin, an analgesic and antiallergic drug, have been compared to those of an inert, undistinguishable placebo in a double-blind study on twelve experienced Sabena (Belgian national airline) Boeing-737 captains who were requested to operate in unexpected scenarios of emergency and ILS instrument approaches in a flight simulator of their company. The test determined, in both medication groups, a significant increase in heart rates reflecting stress in these experimental conditions. The time course variations of heart rate showed values significantly lower in the Neurotropin group in comparison to the placebo group. Nervosity and workload were subjectively determined by pilots' self-assessment and workload was found lower under Neurotropin. Errors and quality of work, as evaluated by the Sabena Chief Instructor, were not significantly different in both groups. Instrument performances were recorded and analyzed by computer and the concordance between real and ideal flight paths was significantly better in the Neurotropin group. The observed Neurotropin effects of reducing the manifestation of stress and maintaining the pilots' performances might be due to a modulation of CNS monoamines, similar to that observed in animals submitted to Specific Alternation of Rhythm in Temperature (SART) stress model. This finding could be therapeutically relevant to the aggravation by anxiety of chronic pain and allergy.
在一项双盲研究中，对12名经验丰富的比利时航空公司（Sabena）波音737机长进行了测试，将镇痛抗过敏药物神经妥乐平（Neurotropin）的效果与一种惰性、无法区分的安慰剂的效果进行了比较。这些机长被要求在公司的飞行模拟器中应对意外的紧急情况和仪表着陆系统（ILS）仪表进近场景。测试发现，在这两种药物组中，反映这些实验条件下压力的心率均显著增加。心率随时间的变化显示，神经妥乐平组的值显著低于安慰剂组。飞行员通过自我评估主观确定紧张程度和工作量，发现使用神经妥乐平后工作量较低。由Sabena首席教练评估的错误和工作质量在两组中没有显著差异。通过计算机记录并分析仪表性能，神经妥乐平组实际飞行路径与理想飞行路径之间的一致性明显更好。观察到的神经妥乐平减轻压力表现并维持飞行员表现的效果，可能是由于中枢神经系统单胺的调节，类似于在经历温度节律特异性改变（SART）应激模型的动物中观察到的情况。这一发现可能在治疗上与焦虑加重慢性疼痛和过敏相关。
