17β-羟基-3-氮杂-A-高-4α-雄甾烯-4-酮对-N，N-双（2-氯乙基）氨基苯氧基乙酸酯（NSC-620480）在P388白血病中的活性。甾体内酰胺在艾氏腹水瘤中的活性。
Activity of 17 beta-hydroxy-3-aza-A-homo-4 alpha-androsten-4-one-p-N, N-bis(2-chloroethyl)aminophenoxyacetate (NSC-620480) in P388 leukemia. Activity of steroidal lactams in Ehrlich tumor.
作者信息
Catsoulacos P, Pairas G
机构信息
University of Patras, School of Health and Sciences, Department of Pharmacy, Greece.
出版信息
Methods Find Exp Clin Pharmacol. 1990 Sep;12(7):501-5.
PMID:2087151
Abstract
A new homo-aza-steroidal ester, 17 beta-hydroxy-3-aza-A-homo-4 alpha-androsten-4-one-p-N,N-bis(2-chloroethyl)aminophenoxyaceta te gives a T/C greater than 125% in the treatment of P388 lymphoid leukemia. Modified and unmodified steroids without alkylating congener have been studied for activity in L1210 leukemia and EAT cells.
摘要
一种新的高氮杂甾体酯，17β-羟基-3-氮杂-A-高-4α-雄甾烯-4-酮对-对-N，N-双（2-氯乙基）氨基苯氧基乙酸酯在治疗P388淋巴细胞白血病时T/C大于125%。已对无烷基化同系物的修饰和未修饰甾体在L1210白血病和艾氏腹水癌细胞中的活性进行了研究。
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