Catsoulacos P, Catsoulacos D
School of Health and Sciences, Department of Pharmacy, University of Patras, Greece.
Anticancer Res. 1993 Jul-Aug;13(4):1203-8.
The homo-aza-steroidal esters of carboxylic derivatives of N, N-bis (2-chloroethyl) aniline are reviewed. In particular, we discuss the antitumor activity of the esters of homo-aza steroids in which the p-N,N-bis(2-chloroethyl)aminophenoxyacetic acid is linked to the C-3 or C-17 position, while the lactam nucleus is linked to the D or A ring of the modified steroid respectively. The current literature indicates clearly that the potential of these esters is due to the synergistic activity of both the lactam and the p-N,N-bis(2-chloroethyl)aminophenoxyacetic acid.
