Department of Psychiatry, St Brigid's Hospital, Ardee, Co., Louth, Republic of Ireland.
Ir J Med Sci. 2012 Mar;181(1):139-41. doi: 10.1007/s11845-010-0587-y. Epub 2010 Sep 26.
A patient with a 28-year history of schizophrenia was treated with a wide range of antipsychotic medications since diagnosis. She had experienced no clinically significant symptomatic relief until she commenced treatment on clozapine. Her psychotic symptoms, self care, and general sense of well-being improved significantly. After 6 years of successful treatment, she developed leukopenia and clozapine was discontinued. The following issues will be discussed in the article: rechallenge with clozapine following leukopenia during previous therapy and the choice of and haematological monitoring needs with other antipsychotic medications after clozapine-induced blood dyscrasia.
一位患有 28 年精神分裂症病史的患者自确诊以来，接受了多种抗精神病药物治疗。直到她开始使用氯氮平治疗，她才经历了没有临床意义的症状缓解。她的精神病症状、自我护理和整体幸福感都有了显著改善。在成功治疗 6 年后，她出现了白细胞减少症，氯氮平被停用。本文将讨论以下问题：在之前的治疗过程中白细胞减少期间重新使用氯氮平，以及在氯氮平引起血液异常后选择其他抗精神病药物和血液学监测需求。
