Faye Abhijeet D, Kirpekar Vivek C, Tadke Rahul, Gawande Sushil, Bhave Sudhir H
Department of Psychiatry, NKP Salve Institute of Medical Sciences and Lata Mangeshkar Hospital, Nagpur, Maharashtra, India.
Indian J Pharmacol. 2018 Mar-Apr;50(2):88-90. doi: 10.4103/ijp.IJP_686_17.
Agranulocytosis is a rare documented side effect of clozapine which can be associated with grave consequences. When it is associated with other blood dyscrasia, prognosis worsens further. In literature, there are very few cases of pancytopenia and bicytopenia caused by clozapine. We present a case of bicytopenia (reduced white and red blood cells' counts) caused by clozapine within a month of therapy and complicated by a infection. Patient improved in 3 weeks after stopping clozapine along with medical management in the Intensive Care Unit. Such side effects, though rare, can be life threatening and warrants intermittent complete blood monitoring besides regular assessment of granulocytes and neutrophils when any patient is prescribed clozapine.
粒细胞缺乏症是氯氮平一种罕见的有记录的副作用，可能会带来严重后果。当它与其他血液系统异常并存时，预后会进一步恶化。在文献中，由氯氮平引起的全血细胞减少症和二系血细胞减少症的病例非常少。我们报告一例在治疗一个月内由氯氮平引起的二系血细胞减少症（白细胞和红细胞计数减少），并伴有感染并发症。患者在停用氯氮平并在重症监护病房进行药物治疗后3周病情好转。这种副作用虽然罕见，但可能危及生命，因此，当给任何患者开氯氮平时，除了定期评估粒细胞和中性粒细胞外，还需间歇性地进行全血细胞监测。
