Department for Oral and Cranio-Maxillo and Facial Plastic Surgery, University of Cologne, Cologne, Germany.
J Surg Oncol. 2010 Oct 1;102(5):443-9. doi: 10.1002/jso.21547.
Carcinoma of the oral cavity is classified according to the TNM staging system of the UICC. The staging system is under continuous revision. The aim of our study was to assess the prognostic value of the UICC sixth edition for oral cancer, which was established in 2003.
Three-hundred treatment-naive patients with oral squamous cell carcinoma (OSCC) of stages I-IVb were reviewed retrospectively. Patients with stage-I disease were treated solely surgically, and patients with stage II-IVb received a multimodal treatment. Overall survival was plotted by Kaplan-Meier analysis. Prognostic factors were identified through univariate and multivariate analysis.
Univariate analysis showed a significant impact of T stage (P = 0.009), N stage (P < 0.001), and UICC stage (P < 0.001) on overall survival. However, no statistical differences were observed between stages T4a and T4b (P = 0.176) and UICC stages IVa and IVb (P = 0.306).
T stage, N stage, and UICC stage grouping are good predictors of overall survival in patients with OSCC. Neither the division of stage T4 into T4a and T4b in the sixth edition nor the split of stage IV into IVa and IVb showed significant differences in overall survival between the subgroups.
口腔癌根据 UICC 的 TNM 分期系统进行分类。该分期系统在不断修订。我们的研究旨在评估 2003 年建立的 UICC 第六版口腔癌的预后价值。
回顾性分析了 300 例未经治疗的 I-IVb 期口腔鳞状细胞癌（OSCC）患者。I 期疾病患者仅接受手术治疗，II-IVb 期患者接受多模式治疗。通过 Kaplan-Meier 分析绘制总生存率。通过单因素和多因素分析确定预后因素。
单因素分析显示 T 分期（P = 0.009）、N 分期（P < 0.001）和 UICC 分期（P < 0.001）对总生存率有显著影响。然而，T4a 和 T4b 之间（P = 0.176）和 UICC 分期 IVa 和 IVb 之间（P = 0.306）没有观察到统计学差异。
T 分期、N 分期和 UICC 分期分组是 OSCC 患者总生存率的良好预测指标。第六版中 T4 分期分为 T4a 和 T4b 以及 IV 分期分为 IVa 和 IVb 并没有在亚组之间显示出总生存率的显著差异。
