综述：脂肪细胞分化和生成的表观遗传调控。
Review: Epigenetic regulation of adipocyte differentiation and adipogenesis.
机构信息
Key Laboratory for Cell Proliferation and Regulation Biology of Ministry of Education, College of Life Sciences, Beijing Normal University, Beijing 100875, China.
出版信息
J Zhejiang Univ Sci B. 2010 Oct;11(10):784-91. doi: 10.1631/jzus.B0900401.
Abstract
It is generally agreed that adipocytes originate from mesenchymal stem cells in what can be divided into two processes: determination and differentiation. In the past decade, many factors associated with epigenetic signals have been proved to be pivotal for the appropriate timing of adipogenesis progression. A large number of coregulators at critical gene promoters set up specific patterns of DNA methylation, histone acetylation and methylation, and nucleosome rearrangement, that act as an epigenetic code to modulate the correct progress of adipocyte differentiation and adipogenesis during adipogenesis. In this review, we focus on the functions and roles of epigenetic processes in preadipocyte differentiation and adipogenesis.
摘要
人们普遍认为脂肪细胞来源于间充质干细胞，可以将其分为两个过程：决定和分化。在过去的十年中，许多与表观遗传信号相关的因素已被证明对于脂肪生成进展的适当时间至关重要。在关键基因启动子处的大量核心调节剂建立了特定的 DNA 甲基化、组蛋白乙酰化和甲基化以及核小体重排模式，作为一种表观遗传密码，调节脂肪细胞分化和脂肪生成过程中脂肪细胞分化的正确进展。在这篇综述中，我们重点讨论了表观遗传过程在前脂肪细胞分化和脂肪生成中的功能和作用。
相似文献
1
Review: Epigenetic regulation of adipocyte differentiation and adipogenesis.综述：脂肪细胞分化和生成的表观遗传调控。
J Zhejiang Univ Sci B. 2010 Oct;11(10):784-91. doi: 10.1631/jzus.B0900401.
2
From Histones to RNA: Role of Methylation in Signal Proteins Involved in Adipogenesis.从组蛋白到RNA：甲基化在脂肪生成相关信号蛋白中的作用
Curr Protein Pept Sci. 2017;18(6):589-598. doi: 10.2174/1389203717666160627082444.
3
Phosphorylated glucosamine inhibits adipogenesis in 3T3-L1 adipocytes.磷酸葡萄糖胺抑制 3T3-L1 脂肪细胞的脂肪生成。
J Nutr Biochem. 2010 May;21(5):438-43. doi: 10.1016/j.jnutbio.2009.01.018. Epub 2009 May 7.
4
Impaired lipid accumulation by trans10, cis12 CLA during adipocyte differentiation is dependent on timing and length of treatment.反式10，顺式12共轭亚油酸在脂肪细胞分化过程中对脂质积累的抑制作用取决于处理的时间和时长。
Biochim Biophys Acta. 2005 Feb 21;1687(1-3):11-22. doi: 10.1016/j.bbalip.2004.08.018.
5
Oleic acid influences the adipogenesis of 3T3-L1 cells via DNA Methylation and may predispose to obesity and obesity-related disorders.油酸通过 DNA 甲基化影响 3T3-L1 细胞的脂肪生成，可能导致肥胖和肥胖相关疾病的易感性。
Lipids Health Dis. 2019 Dec 28;18(1):230. doi: 10.1186/s12944-019-1173-6.
6
OP9 mouse stromal cells rapidly differentiate into adipocytes: characterization of a useful new model of adipogenesis.OP9小鼠基质细胞可迅速分化为脂肪细胞：一种有用的脂肪生成新模型的特征
J Lipid Res. 2006 Feb;47(2):450-60. doi: 10.1194/jlr.D500037-JLR200. Epub 2005 Nov 30.
7
Epigenetic Reprogramming and Inheritance of the Cellular Differentiation Status Following Transient Expression of a Nonfunctional Dominant-Negative Retinoblastoma Mutant in Murine Mesenchymal Stem Cells.短暂表达非功能性显性负性视网膜母细胞瘤突变体后，在小鼠间充质干细胞中细胞分化状态的表观遗传重编程和遗传。
Int J Mol Sci. 2024 Oct 3;25(19):10678. doi: 10.3390/ijms251910678.
8
Persimmon tannin represses 3T3-L1 preadipocyte differentiation via up-regulating expression of miR-27 and down-regulating expression of peroxisome proliferator-activated receptor-γ in the early phase of adipogenesis.柿单宁通过在脂肪生成早期上调miR-27的表达和下调过氧化物酶体增殖物激活受体γ的表达来抑制3T3-L1前脂肪细胞分化。
Eur J Nutr. 2015 Dec;54(8):1333-43. doi: 10.1007/s00394-014-0814-9. Epub 2014 Dec 16.
9
Regulation of brown adipogenesis by the Tgf-β family: involvement of Srebp1c in Tgf-β- and Activin-induced inhibition of adipogenesis.转化生长因子-β家族对棕色脂肪生成的调控：固醇调节元件结合蛋白1c参与转化生长因子-β和激活素诱导的脂肪生成抑制
Biochim Biophys Acta. 2013 Nov;1830(11):5027-35. doi: 10.1016/j.bbagen.2013.06.036. Epub 2013 Jul 10.
10
The transcription factor NKX1-2 promotes adipogenesis and may contribute to a balance between adipocyte and osteoblast differentiation.转录因子 NKX1-2 促进脂肪生成，可能有助于维持脂肪细胞和成骨细胞分化之间的平衡。
J Biol Chem. 2019 Nov 29;294(48):18408-18420. doi: 10.1074/jbc.RA119.007967. Epub 2019 Oct 15.
引用本文的文献
1
Crosstalk Between Antioxidants and Adipogenesis: Mechanistic Pathways and Their Roles in Metabolic Health.抗氧化剂与脂肪生成之间的相互作用：作用机制及其在代谢健康中的作用
Antioxidants (Basel). 2025 Feb 10;14(2):203. doi: 10.3390/antiox14020203.
2
Prevents Adipogenesis by Regulating Histone Acetylation.通过调节组蛋白乙酰化来预防脂肪生成。
Foods. 2025 Jan 7;14(2):160. doi: 10.3390/foods14020160.
3
gene is essential for the larval growth and development of silkworm, .基因对家蚕幼虫的生长和发育至关重要。
Front Physiol. 2024 Mar 7;15:1298869. doi: 10.3389/fphys.2024.1298869. eCollection 2024.
4
The evolutionary impact and influence of oestrogens on adipose tissue structure and function.雌激素对脂肪组织结构和功能的进化影响和作用。
Philos Trans R Soc Lond B Biol Sci. 2023 Sep 11;378(1885):20220207. doi: 10.1098/rstb.2022.0207. Epub 2023 Jul 24.
5
A genome-wide CRISPR screen maps endogenous regulators of PPARG gene expression in bladder cancer.一项全基因组CRISPR筛选绘制了膀胱癌中PPARG基因表达的内源性调节因子图谱。
iScience. 2023 Mar 30;26(5):106525. doi: 10.1016/j.isci.2023.106525. eCollection 2023 May 19.
6
Management of Obesity and Obesity-Related Disorders: From Stem Cells and Epigenetics to Its Treatment.肥胖与肥胖相关疾病的管理：从干细胞和表观遗传学到其治疗。
Int J Mol Sci. 2023 Jan 24;24(3):2310. doi: 10.3390/ijms24032310.
7
Bta-miR-2400 Targets SUMO1 to Affect Yak Preadipocytes Proliferation and Differentiation.Bta-微核糖核酸-2400靶向小泛素样修饰蛋白1以影响牦牛前体脂肪细胞的增殖和分化。
Biology (Basel). 2021 Sep 22;10(10):949. doi: 10.3390/biology10100949.
8
Estrogen receptor alpha regulates the expression of adipogenic genes genetically and epigenetically in rat bone marrow-derived mesenchymal stem cells.雌激素受体α在大鼠骨髓间充质干细胞中通过遗传和表观遗传方式调控脂肪生成基因的表达。
PeerJ. 2021 Sep 10;9:e12071. doi: 10.7717/peerj.12071. eCollection 2021.
9
The protective effects of steamed ginger on adipogenesis in 3T3-L1 cells and adiposity in diet-induced obese mice.蒸制生姜对3T3-L1细胞脂肪生成及饮食诱导肥胖小鼠肥胖的保护作用。
Nutr Res Pract. 2021 Jun;15(3):279-293. doi: 10.4162/nrp.2021.15.3.279. Epub 2021 Jan 12.
10
Mouse Embryonic Fibroblast Adipogenic Potential: A Comprehensive Transcriptome Analysis.小鼠胚胎成纤维细胞成脂潜能：综合转录组分析。
Adipocyte. 2021 Dec;10(1):1-20. doi: 10.1080/21623945.2020.1859789.
本文引用的文献
1
Diet-induced up-regulation of gene expression in adipocytes without changes in DNA methylation.饮食诱导脂肪细胞中基因表达上调，而DNA甲基化无变化。
Kobe J Med Sci. 2009 Mar 10;54(5):E241-9.
2
Expression of the peroxisome proliferator activated receptor gamma gene is repressed by DNA methylation in visceral adipose tissue of mouse models of diabetes.在糖尿病小鼠模型的内脏脂肪组织中，过氧化物酶体增殖物激活受体γ基因的表达受到DNA甲基化的抑制。
BMC Biol. 2009 Jul 10;7:38. doi: 10.1186/1741-7007-7-38.
3
Histone methylation regulator PTIP is required for PPARgamma and C/EBPalpha expression and adipogenesis.组蛋白甲基化调节因子PTIP是PPARγ和C/EBPα表达及脂肪生成所必需的。
Cell Metab. 2009 Jul;10(1):27-39. doi: 10.1016/j.cmet.2009.05.010.
4
Epigenetic regulation of adipocyte differentiation by a Rho guanine nucleotide exchange factor, WGEF.一种Rho鸟嘌呤核苷酸交换因子WGEF对脂肪细胞分化的表观遗传调控
PLoS One. 2009 Jun 5;4(6):e5809. doi: 10.1371/journal.pone.0005809.
5
Adipogenesis licensing and execution are disparately linked to cell proliferation.脂肪生成的起始许可与执行过程与细胞增殖的联系并不相同。
Cell Res. 2009 Feb;19(2):216-23. doi: 10.1038/cr.2008.319.
6
Regulation of cyclin D1 and Wnt10b gene expression by cAMP-responsive element-binding protein during early adipogenesis involves differential promoter methylation.在早期脂肪生成过程中，环磷腺苷反应元件结合蛋白对细胞周期蛋白D1和Wnt10b基因表达的调控涉及不同的启动子甲基化。
J Biol Chem. 2008 Dec 12;283(50):35096-105. doi: 10.1074/jbc.M806423200. Epub 2008 Oct 27.
7
Peroxisome Proliferators-Activated Receptor (PPAR) Modulators and Metabolic Disorders.过氧化物酶体增殖物激活受体（PPAR）调节剂与代谢紊乱
PPAR Res. 2008;2008:679137. doi: 10.1155/2008/679137.
8
Gene-environment interactions and epigenetic basis of human diseases.人类疾病的基因-环境相互作用及表观遗传基础。
Curr Issues Mol Biol. 2008;10(1-2):25-36.
9
Regulation of the brown and white fat gene programs through a PRDM16/CtBP transcriptional complex.通过PRDM16/CtBP转录复合物对棕色和白色脂肪基因程序的调控。
Genes Dev. 2008 May 15;22(10):1397-409. doi: 10.1101/gad.1666108.
10
C/EBPs: recipients of extracellular signals through proteome modulation.C/EBPs：通过蛋白质组调节接收细胞外信号的物质。
Curr Opin Cell Biol. 2008 Apr;20(2):180-5. doi: 10.1016/j.ceb.2008.02.002. Epub 2008 Mar 21.
Zotero 插件