[费氏弧菌lux操纵子基因在大肠杆菌细胞中表达的蛋白水解调控]
[Proteolytic control of expression of Vibrio fischeri lux-operon genes in Escherichia coli cells].
作者信息
Mel'kina O E, Manukhov I V, Zavil'gel'skiĭ G B
出版信息
Genetika. 2010 Aug;46(8):1050-6.
PMID:20873201
Abstract
The key elements of the regulatory system activating expression of the lux-operon genes in the sea bacteria Vibrio fischeri are the LuxR protein (an activator oftranscription) and N-(3-oxohexanoyl) L-homoserine lactone (an autoinducer, AI). It is shown that the ATP-dependent proteases ClpXP and Lon take part in the negative control of expression of the lux-operon genes and that AI protects the LuxR protein from proteolysis.
摘要
在海洋细菌费氏弧菌中激活lux操纵子基因表达的调控系统的关键元件是LuxR蛋白（一种转录激活因子）和N-（3-氧代己酰基）-L-高丝氨酸内酯（一种自诱导物，AI）。研究表明，ATP依赖性蛋白酶ClpXP和Lon参与lux操纵子基因表达的负调控，并且AI可保护LuxR蛋白不被蛋白酶解。
Zotero 插件