Giamberardino Maria Adele, Vecchiet Leonardo, Albe-Fessard Denise
Institute of Medical Pathophysiology, University of Chieti, ChietiItaly.
Pain. 1990 Nov;43(2):227-234. doi: 10.1016/0304-3959(90)91076-U.
An animal model of muscular hyperalgesia was developed. In humans, this disorder follows painful crises due to ureteral calculosis. Changes in vocalization thresholds to electrical stimulation of the obliquus externus muscle of both sides were studied in a group of rats with chronically implanted muscles before and after the production of a stone in one ureter. In another group of rats with implanted muscles, it had been verified preliminarily that these thresholds did not vary widely from day to day. On the contrary, a significant lowering in threshold (max 31%) in the muscle ipsilateral to the implanted ureter appeared the day after the production of the stone and persisted for the subsequent 10 days of observation, although less pronounced during the last 5 days. Hypersensitivity to manual pressure was also observed, mainly in the ipsilateral muscle, in most rats during the same period. In order to differentiate between the effects due to the presence of the stone in the ureteral lumen and those due to the spontaneous occlusion which frequently occurred in the implanted ureter, 2 other groups of rats were studied. In one, a unilateral ureteral ligature was performed; in the other, the production of a stone was combined with a ligature (placed distally to the stone). Ligature alone never induced any hyperalgesic effect. Stone plus ligature produced a marked hyperalgesia (max 39%) in the ipsilateral muscle, which lasted for only 5 days. It is concluded that the ureteral stone is the factor responsible for the appearance of muscular hyperalgesia.
建立了肌肉痛觉过敏的动物模型。在人类中，这种疾病继发于输尿管结石症引起的疼痛发作。在一组长期植入肌肉的大鼠中，研究了一侧输尿管结石形成前后两侧腹外斜肌对电刺激的发声阈值变化。在另一组植入肌肉的大鼠中，已初步证实这些阈值在一天内变化不大。相反，结石形成后的第二天，植入输尿管同侧的肌肉阈值显著降低（最大降低31%），并在随后的10天观察期内持续存在，尽管在最后5天不太明显。在同一时期，大多数大鼠还观察到对手动压力的超敏反应，主要在同侧肌肉中。为了区分输尿管腔内结石存在的影响和植入输尿管中频繁发生的自发性梗阻的影响，研究了另外两组大鼠。一组进行单侧输尿管结扎；另一组将结石形成与结扎（置于结石远端）相结合。单独结扎从未产生任何痛觉过敏效应。结石加结扎在同侧肌肉中产生明显的痛觉过敏（最大39%），持续仅5天。结论是输尿管结石是导致肌肉痛觉过敏出现的因素。
