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大鼠输尿管刺激后的肌肉痛觉过敏和痛觉减退

Muscular hyperalgesia and hypoalgesia after stimulation of the ureter in rats.

作者信息

Giamberardino M A, Rampin O, Laplace J P, Vecchiet L, Albe-Fessard D

机构信息

Groupe de Neurobiologie Appliquée INRA, Jouy en Josas, France.

出版信息

Neurosci Lett. 1988 Apr 22;87(1-2):29-34. doi: 10.1016/0304-3940(88)90140-1.

DOI:10.1016/0304-3940(88)90140-1
PMID:3380339
Abstract

Vocalization electric thresholds were measured bilaterally in muscles of the lower back and in the tail after electrical stimulation of the left ureter in rats implanted with electrodes. 'Painful' stimulation immediately produced a hyperalgesia lasting about half an hour in the left lower back muscles and tail, followed by a 10 min hypoalgesia limited to the back muscles. No modification or only a delayed hypoalgesia appeared in the right muscle. Strong but 'non-painful' stimulation produced no effect or gave rise to an immediate hypoalgesia in the left muscle. Weak non-painful stimulation produced a delayed hypoalgesia in the tail.

摘要

在植入电极的大鼠中,电刺激左侧输尿管后,双侧测量下背部肌肉和尾部肌肉的发声电阈值。“疼痛性”刺激立即在左下背部肌肉和尾部产生持续约半小时的痛觉过敏,随后是仅局限于背部肌肉的10分钟痛觉减退。右侧肌肉无变化或仅有延迟性痛觉减退。强烈但“非疼痛性”刺激在左侧肌肉中无作用或引起立即性痛觉减退。微弱的非疼痛性刺激在尾部产生延迟性痛觉减退。

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