Fichera A, D'Agata A, Praticò G, Curreri R, Sciacca F
Clinica Pediatrica 2a, Università di Catania, Italia.
Pediatr Med Chir. 1990 Sep-Oct;12(5):539-41.
The authors describe a two months aged patient affected by cow's milk protein intolerance (CMPI) with serious haemorrhagic manifestations. As blood coagulative laboratory findings demonstrated a prolongation of P.T. and P.T.T. with a marked reduction of vitamin K-dependent factors only, the authors believe these bleeding manifestations secondary to a case of late haemorrhagic disease of the newborn. Vitamin K treatment determined a rapid normalization of haemorrhagic symptoms and laboratory clotting tests, without any alteration of these ones during the patient's follow-up too. The authors suggest that blood coagulative pattern must be investigated in all CMPI cases, especially in the ones with a precocious onset of clinical symptoms. In the cases with vitamin K-dependent factors deficiency the treatment is immediately necessary, while in other cases a daily dietary supplementation or a vitamin K weekly or monthly injection could be enough in order to prevent any further vitamin K-dependent factors deficiency.
作者描述了一名两个月大的患有牛奶蛋白不耐受（CMPI）且有严重出血表现的患者。由于血液凝固实验室检查结果显示仅凝血酶原时间（P.T.）和部分凝血活酶时间（P.T.T.）延长，且维生素K依赖因子显著减少，作者认为这些出血表现是新生儿晚期出血性疾病的继发症状。维生素K治疗使出血症状和实验室凝血检查迅速恢复正常，在患者随访期间这些指标也未出现任何变化。作者建议，对于所有CMPI病例，尤其是临床症状早熟的病例，必须进行血液凝固模式检查。在维生素K依赖因子缺乏的病例中，立即进行治疗是必要的，而在其他病例中，每日膳食补充或每周或每月注射维生素K可能足以预防任何进一步的维生素K依赖因子缺乏。
