Endocrinology and Metabolism Research Center, Shariati Hospital, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
Metab Syndr Relat Disord. 2010 Oct;8(5):411-6. doi: 10.1089/met.2009.0112.
Despite existing epidemiologic data concerning the increased incidence of breast cancer in diabetes type 2, the association between insulin resistance and breast carcinogenesis is not yet well defined. In this cross-sectional study, we examined the homeostatic model assessment values of insulin resistance (HOMA-IR) among 82 patients with malignant breast tumor, 48 subjects with benign breast mass, and 838 healthy Iranian women. One hundred and thirty (n = 130) surgical inpatients of Tehran Central Cancer Institute (Tehran, Iran) were evaluated preoperatively. Healthy subjects were nondiabetic, nonhypertensive women aged 20-77 years from four different locations in Tehran. Age and central obesity-adjusted HOMA-IR values were 3.6 [95% confidence interval (CI), 2.8-4.4], 2.3 (1.7-2.9), and 1.7(1.6-1.8) correspondingly in subjects with malignant breast tumor, those with benign breast mass, and healthy subjects. The interaction effect of age on the association between breast mass (malignant/ benign /no breast mass) with HOMA-IR values was significant [F(54) = 10, P < 0.001, partial eta squared = 0.03]. The interaction of central obesity on this association was also significant [F(54) = 37, P < 0.001, partial eta squared = 0.11]. We conclude that the noted linkage between insulin resistance and breast cancer may indicate an underlying pathology of mammary carcinogenesis.
尽管有关于 2 型糖尿病中乳腺癌发病率增加的现有流行病学数据，但胰岛素抵抗与乳腺癌发生之间的关系尚未明确。在这项横断面研究中，我们检查了 82 例恶性乳腺肿瘤患者、48 例良性乳腺肿块患者和 838 例健康伊朗女性的胰岛素抵抗稳态模型评估值（HOMA-IR）。德黑兰中央癌症研究所（伊朗德黑兰）的 130 名（n=130）住院手术患者在术前进行了评估。健康受试者为年龄在 20-77 岁之间、无糖尿病和高血压的女性，来自德黑兰的四个不同地点。经年龄和中心性肥胖校正的 HOMA-IR 值在患有恶性乳腺肿瘤、良性乳腺肿块和健康受试者中的值分别为 3.6 [95%置信区间（CI），2.8-4.4]、2.3（1.7-2.9）和 1.7（1.6-1.8）。年龄对乳腺肿块（恶性/良性/无乳腺肿块）与 HOMA-IR 值之间关联的交互作用具有统计学意义[F(54)=10，P<0.001，部分 eta 平方=0.03]。这种关联中中心性肥胖的交互作用也具有统计学意义[F(54)=37，P<0.001，部分 eta 平方=0.11]。我们得出结论，胰岛素抵抗与乳腺癌之间的这种关联可能表明乳腺癌发生的潜在病理学。
