Gonullu Guzin, Ersoy Canan, Ersoy Alpaslan, Evrensel Turkkan, Basturk Bilkay, Kurt Ender, Oral Barboros, Gokgoz Sehsuvar, Manavoglu Osman
Department of Medical Oncology, Uludağ University Medical School, Bursa, Turkey.
Cytokine. 2005 Aug 21;31(4):264-9. doi: 10.1016/j.cyto.2005.05.003.
Insulin resistance (IR) and obesity may be risk factors for breast cancer. The mechanism of IR in patients with cancer has not been fully clarified yet. This study was conducted to evaluate the possible role of circulating cytokines; tumor necrosis factor-alpha (TNF-alpha) and interleukin 6 (IL-6) in inducing IR in 20 overweight or obese patients with early stage breast cancer and to compare their levels with that of body mass index matched 20 healthy controls. IR was calculated by homeostasis model assessment (HOMA) method. Four groups were formed according to a 2.7 HOMA-IR cut-off value as breast cancer with or without IR and controls with or without IR. IL-6 and HOMA-IR values were found to be higher in breast cancer patients with IR compared to other groups. There was no significant difference in TNF-alpha levels between groups. HOMA-IR values correlated with estradiol and IL-6 levels in all breast cancer patients but not TNF-alpha. HOMA-IR values, serum insulin, estradiol and IL-6 levels in the receptor positive group were significantly higher than those of the receptor negative group. These results suggested a possible contribution of endogenous IL-6 production and hyperinsulinemia to the development of breast cancer in overweight or obese patients with prominent IR.
胰岛素抵抗（IR）和肥胖可能是乳腺癌的危险因素。癌症患者中IR的机制尚未完全阐明。本研究旨在评估循环细胞因子；肿瘤坏死因子-α（TNF-α）和白细胞介素6（IL-6）在20例超重或肥胖的早期乳腺癌患者中诱导IR的可能作用，并将其水平与20名体重指数匹配的健康对照者进行比较。IR通过稳态模型评估（HOMA）方法计算。根据2.7的HOMA-IR临界值分为四组，即有或无IR的乳腺癌患者以及有或无IR的对照者。与其他组相比，有IR的乳腺癌患者的IL-6和HOMA-IR值更高。各组之间TNF-α水平无显著差异。在所有乳腺癌患者中，HOMA-IR值与雌二醇和IL-6水平相关，但与TNF-α无关。受体阳性组的HOMA-IR值、血清胰岛素、雌二醇和IL-6水平显著高于受体阴性组。这些结果表明，内源性IL-6产生和高胰岛素血症可能对超重或肥胖且有明显IR的患者患乳腺癌有影响。
