Department of Pharmaceutical Sciences, University of Bologna, Via Belmeloro 6, 40126 Bologna, Italy.
Crit Rev Microbiol. 2011 Feb;37(1):1-14. doi: 10.3109/1040841X.2010.501760. Epub 2010 Sep 29.
In this review, we discuss the multifactorial role of intestinal microbiota in colorectal cancer. The peculiar metabolism of dietary compounds of the individual microbiota complement, its overall immunostimulation and immunomodulatory activity, and eventually the production of toxins that perturb the regulation of cell growth, define the balance of positive and negative risk factors for colorectal cancer development. Moreover, shaping the composition of the human intestinal microbiota, diet has an indirect impact in determining the balance between health and disease. The integration of diet, microbial, and host factors in a system approach is mandatory to determine the overall balance of risk and protective factors for colorectal cancer onset.
在这篇综述中，我们讨论了肠道微生物群在结直肠癌中的多因素作用。个体微生物群的饮食化合物的特殊代谢、其整体免疫刺激和免疫调节活性，以及最终产生扰乱细胞生长调节的毒素，定义了结直肠癌发展的正、负风险因素的平衡。此外，饮食通过影响人类肠道微生物群的组成，对决定健康与疾病之间的平衡有间接影响。为了确定结直肠癌发病的风险和保护因素的整体平衡，必须采用饮食、微生物和宿主因素的系统方法进行整合。
