Clinical Medical College, Yangzhou University, Yangzhou, Jiangsu Province, China.
Department of General Surgery, Institute of General Surgery, Clinical Medical College, Yangzhou University, Northern Jiangsu People's Hospital, Yangzhou, China.
Int J Cancer. 2019 Oct 15;145(8):2032-2041. doi: 10.1002/ijc.32017. Epub 2019 Jan 15.
Colorectal cancer is the third largest cancer in worldwide and has been proven to be closely related to the intestinal microbiota. Many reports and clinical studies have shown that intestinal microbial behavior may lead to pathological changes in the host intestines. The changes can be divided into epigenetic changes and carcinogenic changes at the gene level, which ultimately promote the production and development of colorectal cancer. This article reviews the pathways of microbial signaling in the intestinal epithelial barrier, the role of microbiota in inflammatory colorectal tumors, and typical microbial carcinogenesis. Finally, by gaining a deeper understanding of the intestinal microbiota, we hope to achieve the goal of treating colorectal cancer using current microbiota technologies, such as fecal microbiological transplantation.
结直肠癌是全球第三大癌症，已被证明与肠道微生物群密切相关。许多报告和临床研究表明，肠道微生物的行为可能导致宿主肠道的病理变化。这些变化可以分为基因水平的表观遗传变化和致癌变化，最终促进结直肠癌的产生和发展。本文综述了微生物信号在肠道上皮屏障中的途径、微生物群在炎症性结直肠肿瘤中的作用以及典型的微生物致癌作用。最后，通过深入了解肠道微生物群，我们希望利用当前的微生物组技术，如粪便微生物移植，来达到治疗结直肠癌的目的。
