Department of Dermatology, Deventer Hospital, N. Bolkesteinlaan 75, 7416 SE Deventer, The Netherlands.
Br J Dermatol. 2011 Jan;164(1):170-5. doi: 10.1111/j.1365-2133.2010.10071.x.
Hidradenitis suppurativa (HS) is a distressing chronic inflammatory skin disorder which affects predominantly the groins and axillae. In analogy to acne, oral isotretinoin has been considered in the treatment of HS, although there are strong indications that this drug has only a very limited therapeutic effect. During the past 25 years scattered case reports have described promising results of treatment with acitretin.
To evaluate the long-term efficacy of acitretin monotherapy.
A retrospective study in 12 patients with severe, recalcitrant HS who were treated with acitretin for 9-12 months at one Dermatology Centre in the Netherlands between 2005 and 2007 and were followed up to 4 years. The patients were men and infertile women. The efficacy of the treatment was rated by the patients on global maximum pain of nodules and abscesses on a visual analogue scale (VAS) as well as by physician global assessment.
All 12 patients achieved remission and experienced a significant decrease in pain as assessed by VAS. In nine patients long-lasting improvement was observed, with no recurrence of lesions after 6 months (n = 1), 1 year (n = 3), >2 years (n = 2), >3 years (n = 2) and >4 years (n = 1).
Acitretin appears to be an effective treatment for refractory HS, leading to reduction of pain from painful nodules and reducing the extent of the disease for a prolonged period.
化脓性汗腺炎（HS）是一种令人痛苦的慢性炎症性皮肤病，主要影响腹股沟和腋窝。与痤疮类似，口服异维 A 酸已被考虑用于 HS 的治疗，尽管有强有力的证据表明，这种药物的治疗效果非常有限。在过去的 25 年中，散在的病例报告描述了阿维 A 酯治疗的有希望的结果。
评估阿维 A 酯单药治疗的长期疗效。
对 2005 年至 2007 年间荷兰一家皮肤科中心的 12 例严重、难治性 HS 患者进行回顾性研究，这些患者接受阿维 A 酯治疗 9-12 个月，并随访 4 年。这些患者均为男性和不育女性。通过患者在视觉模拟量表（VAS）上对结节和脓肿的最大疼痛的总体评分以及医生的总体评估来评价治疗的疗效。
所有 12 例患者均达到缓解，VAS 评估疼痛显著减轻。9 例患者观察到长期改善，在 6 个月（n = 1）、1 年（n = 3）、>2 年（n = 2）、>3 年（n = 2）和>4 年（n = 1）后无病变复发。
阿维 A 酯似乎是治疗难治性 HS 的有效方法，可减轻疼痛性结节的疼痛，并在较长时间内减轻疾病的严重程度。
